244661

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 51394..51958 Replicon plasmid pAT04-a
Accession NZ_CP097060
Organism Enterococcus faecalis strain AT04

Toxin (Protein)


Gene name zeta Uniprot ID A0A0M2A908
Locus tag M2902_RS13915 Protein ID WP_010724880.1
Coordinates 51668..51958 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID Q9AL01
Locus tag M2902_RS13910 Protein ID WP_002331065.1
Coordinates 51394..51666 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2902_RS13880 (M2902_13880) 46693..47601 + 909 WP_001255866.1 aminoglycoside nucleotidyltransferase ANT(6)-Ia -
M2902_RS13885 (M2902_13885) 47598..48140 + 543 WP_248851561.1 streptothricin N-acetyltransferase Sat4 -
M2902_RS13890 (M2902_13890) 48233..49027 + 795 WP_001096887.1 aminoglycoside O-phosphotransferase APH(3')-IIIa -
M2902_RS13895 (M2902_13895) 49303..49875 + 573 WP_001079938.1 HTH domain-containing protein -
M2902_RS13900 (M2902_13900) 50173..51069 + 897 WP_002334978.1 AAA family ATPase -
M2902_RS13905 (M2902_13905) 51168..51377 + 210 WP_000527318.1 peptide-binding protein -
M2902_RS13910 (M2902_13910) 51394..51666 + 273 WP_002331065.1 antitoxin Antitoxin
M2902_RS13915 (M2902_13915) 51668..51958 + 291 WP_010724880.1 zeta toxin family protein Toxin
M2902_RS13920 (M2902_13920) 51986..52666 + 681 WP_001015311.1 IS6-like element IS1216 family transposase -
M2902_RS13925 (M2902_13925) 52700..53491 - 792 WP_021164592.1 protein rep -
M2902_RS13930 (M2902_13930) 53736..54998 - 1263 WP_000119405.1 MobV family relaxase -
M2902_RS13935 (M2902_13935) 55562..56938 - 1377 WP_001574277.1 tetracycline efflux MFS transporter Tet(L) -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid ant(6)-Ia / aph(3')-III / tet(L) / tet(M) prgB/asc10 1..69215 69215
- inside IScluster/Tn ant(6)-Ia / aph(3')-III / tet(L) / tet(M) - 44997..60430 15433


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-81)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10902.37 Da        Isoelectric Point: 5.8599

>T244661 WP_010724880.1 NZ_CP097060:51668-51958 [Enterococcus faecalis]
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAIFEETQGNVIVIDNDTFKQQHPNFDELV
KRFCCKVLNLLSNKVE

Download         Length: 291 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10733.17 Da        Isoelectric Point: 4.4865

>AT244661 WP_002331065.1 NZ_CP097060:51394-51666 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYS
KQILNKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2A908

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZL55

References