Detailed information of TA system TA024466

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 8587736..8588286
• Replicon: chromosome
• Accession: NC_013595
• Organism: Streptosporangium roseum DSM 43021

Toxin (Protein)

• Gene name: relE
• Uniprot ID: D2ASY2
• Locus tag: SROS_RS37585
• Protein ID: WP_012894189.1
• Coordinates: 8587736..8588011 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: SROS_RS37590
• Protein ID: WP_148269323.1
• Coordinates: 8588008..8588286 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SROS_RS37565	8582757..8583647	+	891	WP_012894184.1	DMT family transporter	-
SROS_RS37570	8583848..8584195	+	348	WP_012894185.1	hypothetical protein	-
SROS_RS37575	8584328..8585119	-	792	WP_012894186.1	class II aldolase/adducin family protein	-
SROS_RS37580	8585432..8587636	+	2205	WP_148269804.1	accessory Sec system translocase SecA2	-
SROS_RS37585	8587736..8588011	-	276	WP_012894189.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SROS_RS37590	8588008..8588286	-	279	WP_148269323.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
SROS_RS37595	8588383..8588775	-	393	WP_012894191.1	hypothetical protein	-
SROS_RS50315	8588772..8589005	-	234	WP_143121272.1	hypothetical protein	-
SROS_RS37605	8589328..8590143	+	816	WP_012894192.1	helix-turn-helix transcriptional regulator	-
SROS_RS37610	8590298..8591059	+	762	WP_043653745.1	hypothetical protein	-
SROS_RS37615	8591189..8592091	-	903	WP_012894194.1	aliphatic sulfonate ABC transporter substrate-binding protein	-
SROS_RS37620	8592088..8593239	-	1152	WP_012894195.1	LLM class flavin-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (10-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10661.24 Da
• Isoelectric Point: 10.6005

>T24466 WP_012894189.1 NC_013595:c8588011-8587736 [Streptosporangium roseum DSM 43021]
VSERYELHLTRRARQDLAERLPAKVVRAVWEFITGPLLDNPRRVGKPLDEPLAPQWSARRGDYRVLYLIDDGRILVQVVT
VQHRADAYRSR

Nucleotide

• Length: 276 bp

>T24466 NC_013595:c8588011-8587736 [Streptosporangium roseum DSM 43021]
GTGAGCGAGCGATACGAACTCCACCTCACCCGCCGCGCCAGACAGGATCTCGCCGAACGCCTGCCGGCGAAAGTCGTGCG
GGCGGTCTGGGAGTTCATCACCGGACCGCTGCTGGACAACCCTCGCCGGGTCGGCAAACCCCTCGACGAACCTCTCGCTC
CCCAATGGTCCGCGCGTCGCGGCGACTACCGGGTTCTCTACCTGATCGACGATGGCCGGATCCTGGTCCAGGTGGTCACC
GTCCAGCACCGAGCGGACGCGTACAGATCCCGCTAG

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 9975.30 Da
• Isoelectric Point: 4.5431

>AT24466 WP_148269323.1 NC_013595:c8588286-8588008 [Streptosporangium roseum DSM 43021]
MTVLPLADARARLSSIVESAVSTHERFEITRNGVPAAVLVAVDDYETMREMIEILASAETVAALREGIADLEAGRTHSQA
EVEAELRRAGRL

Nucleotide

• Length: 279 bp

>AT24466 NC_013595:c8588286-8588008 [Streptosporangium roseum DSM 43021]
ATGACAGTTCTTCCTCTGGCGGACGCCCGAGCCCGGCTCTCGAGCATCGTCGAGTCCGCCGTCAGCACGCATGAGCGATT
CGAGATCACCCGTAACGGCGTGCCCGCGGCCGTGCTGGTCGCCGTGGACGACTACGAGACGATGCGAGAGATGATCGAGA
TCCTCGCCTCCGCCGAAACCGTGGCGGCCCTCCGTGAGGGGATCGCCGATCTGGAGGCAGGACGTACCCACTCCCAGGCC
GAGGTGGAAGCCGAGCTCCGCCGGGCCGGCCGTCTGTGA

Structures

Toxin

• AlphaFold DB: D2ASY2