Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2741178..2741749 Replicon chromosome
Accession NZ_CP097059
Organism Enterococcus faecalis strain AT04

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag M2902_RS13155 Protein ID WP_002354774.1
Coordinates 2741178..2741519 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID R3JGB1
Locus tag M2902_RS13160 Protein ID WP_002354773.1
Coordinates 2741519..2741749 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2902_RS13150 (2737193) 2737193..2740807 - 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -
M2902_RS13155 (2741178) 2741178..2741519 - 342 WP_002354774.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
M2902_RS13160 (2741519) 2741519..2741749 - 231 WP_002354773.1 hypothetical protein Antitoxin
M2902_RS13165 (2742156) 2742156..2742371 - 216 WP_002358974.1 zinc ribbon domain-containing protein -
M2902_RS13170 (2742510) 2742510..2743502 + 993 WP_002358973.1 biotin--[acetyl-CoA-carboxylase] ligase -
M2902_RS13175 (2743569) 2743569..2744201 - 633 WP_002358972.1 RloB family protein -
M2902_RS13180 (2744210) 2744210..2745505 - 1296 WP_002396787.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13156.40 Da        Isoelectric Point: 9.3984

>T244641 WP_002354774.1 NZ_CP097059:c2741519-2741178 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETQGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.67 Da        Isoelectric Point: 4.3313

>AT244641 WP_002354773.1 NZ_CP097059:c2741749-2741519 [Enterococcus faecalis]
MLTTKSRRQGSSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2A812

References