244638

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_26(antitoxin)
Location 2372399..2373094 Replicon chromosome
Accession NZ_CP097059
Organism Enterococcus faecalis strain AT04

Toxin (Protein)


Gene name IrrE Uniprot ID -
Locus tag M2902_RS11425 Protein ID WP_104802092.1
Coordinates 2372750..2373094 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag M2902_RS11420 Protein ID WP_002373919.1
Coordinates 2372399..2372731 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2902_RS11370 (2367870) 2367870..2368685 - 816 WP_161972151.1 PD-(D/E)XK nuclease-like domain-containing protein -
M2902_RS11375 (2368648) 2368648..2369613 - 966 WP_002415270.1 RecT family recombinase -
M2902_RS11380 (2369714) 2369714..2369938 - 225 WP_104802087.1 hypothetical protein -
M2902_RS11385 (2369935) 2369935..2370234 - 300 WP_002388460.1 hypothetical protein -
M2902_RS11390 (2370301) 2370301..2370480 - 180 WP_104802088.1 hypothetical protein -
M2902_RS11395 (2370515) 2370515..2370784 - 270 WP_002365131.1 hypothetical protein -
M2902_RS11400 (2370860) 2370860..2371174 + 315 WP_010776102.1 hypothetical protein -
M2902_RS14050 (2371155) 2371155..2371283 - 129 WP_010776103.1 hypothetical protein -
M2902_RS11405 (2371430) 2371430..2371612 + 183 WP_104802089.1 hypothetical protein -
M2902_RS11410 (2371604) 2371604..2371906 - 303 WP_104802090.1 hypothetical protein -
M2902_RS11415 (2371919) 2371919..2372101 - 183 WP_104802091.1 hypothetical protein -
M2902_RS11420 (2372399) 2372399..2372731 + 333 WP_002373919.1 helix-turn-helix transcriptional regulator Antitoxin
M2902_RS11425 (2372750) 2372750..2373094 + 345 WP_104802092.1 ImmA/IrrE family metallo-endopeptidase Toxin
M2902_RS11430 (2373181) 2373181..2373363 + 183 WP_010817602.1 hypothetical protein -
M2902_RS11435 (2373365) 2373365..2374012 - 648 WP_104802093.1 hypothetical protein -
M2902_RS11440 (2374202) 2374202..2375383 + 1182 WP_010707133.1 site-specific integrase -
M2902_RS11445 (2375486) 2375486..2375635 - 150 WP_002356321.1 50S ribosomal protein L33 -
M2902_RS11450 (2375761) 2375761..2377896 - 2136 WP_002359399.1 penicillin-binding protein 2 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2342714..2375383 32669


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(21-86)

Antitoxin

Cro/C1-type helix-turn-helix domain

(5-59)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13626.61 Da        Isoelectric Point: 5.6177

>T244638 WP_104802092.1 NZ_CP097059:2372750-2373094 [Enterococcus faecalis]
MKSIKELVEEYNVELVFTTLNKRACFDPTYGIIFVNQNLTPSEQEEAIYHELKHVKDHVDIMTLYKIPVFRSKMESEAEQ
YMFRSLIEKYEGQYNYSNVIAHYNLKMGQEVYLK

Download         Length: 345 bp

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12734.28 Da        Isoelectric Point: 5.2423

>AT244638 WP_002373919.1 NZ_CP097059:2372399-2372731 [Enterococcus faecalis]
MNTYEIIKELTKRKKMSIRQLEITLGYSNGYFSKWKKVSPNSEGLQKVADYFNVSVDYLLGRTDNTKATDEKNSDDLDDV
LDNVMSFDGEPLDDHDREVIRAYLKGRFGK

Download         Length: 333 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References