Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 438618..439755 Replicon chromosome
Accession NZ_CP097059
Organism Enterococcus faecalis strain AT04

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag M2902_RS02195 Protein ID WP_032495456.1
Coordinates 438892..439755 (+) Length 288 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID R2XCR7
Locus tag M2902_RS02190 Protein ID WP_000301765.1
Coordinates 438618..438890 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2902_RS02155 (433687) 433687..435519 + 1833 Protein_401 DNA topoisomerase -
M2902_RS02160 (435653) 435653..435892 + 240 WP_002425012.1 peptide-binding protein -
M2902_RS02165 (435956) 435956..436024 + 69 WP_011100846.1 23S rRNA methyltransferase attenuator leader peptide ErmL -
M2902_RS02170 (436149) 436149..436886 + 738 WP_032495453.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) -
M2902_RS02175 (437056) 437056..437316 + 261 Protein_405 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
M2902_RS02180 (437398) 437398..438294 + 897 WP_002387620.1 ParA family protein -
M2902_RS02185 (438386) 438386..438601 + 216 WP_001835296.1 peptide-binding protein -
M2902_RS02190 (438618) 438618..438890 + 273 WP_000301765.1 antitoxin Antitoxin
M2902_RS02195 (438892) 438892..439755 + 864 WP_032495456.1 zeta toxin family protein Toxin
M2902_RS02200 (440196) 440196..440513 + 318 WP_002338433.1 hypothetical protein -
M2902_RS02205 (441047) 441047..441544 + 498 WP_010713926.1 molecular chaperone DnaJ -
M2902_RS02210 (441579) 441579..441701 + 123 WP_159111623.1 DpnD/PcfM family protein -
M2902_RS02215 (441755) 441755..442435 + 681 WP_001015311.1 IS6-like element IS1216 family transposase -
M2902_RS02220 (442480) 442480..443100 - 621 Protein_414 MFS transporter -
M2902_RS02225 (443301) 443301..443711 - 411 WP_231428140.1 protein rep -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element erm(B) / tet(O/W/32/O) / fexB / optrA bsh 401696..504060 102364
- inside IScluster/Tn erm(B) / tet(O/W/32/O) / fexB / optrA bsh 436149..485091 48942


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-214)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 288 a.a.        Molecular weight: 32444.13 Da        Isoelectric Point: 6.9964

>T244635 WP_032495456.1 NZ_CP097059:438892-439755 [Enterococcus faecalis]
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAIFEETQGNVIVIDNDTFKQQHPNFDELV
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGIIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISPKETLEKELNRKVASKEIQ
PTLERIEQKMILNKHQETPEFKAIQQKLESLQPPTPPIPKTPKLPGI

Download         Length: 864 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10721.25 Da        Isoelectric Point: 6.4676

>AT244635 WP_000301765.1 NZ_CP097059:438618-438890 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 3Q8X
PDB 1GVN
AlphaFold DB A0A829F0A3

References