Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-DinJ
Location 35307..35841 Replicon plasmid pAT09-a
Accession NZ_CP097057
Organism Enterococcus faecalis strain AT09

Toxin (Protein)


Gene name relE Uniprot ID R3JX52
Locus tag M2903_RS13785 Protein ID WP_002360769.1
Coordinates 35566..35841 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID R3H6P0
Locus tag M2903_RS13780 Protein ID WP_002369771.1
Coordinates 35307..35573 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2903_RS13750 (M2903_13750) 31410..32195 + 786 WP_000803546.1 winged helix-turn-helix domain-containing protein -
M2903_RS13755 (M2903_13755) 32201..32689 + 489 WP_002368088.1 hypothetical protein -
M2903_RS13760 (M2903_13760) 33281..33547 + 267 WP_002368091.1 hypothetical protein -
M2903_RS13765 (M2903_13765) 33580..34074 + 495 WP_002368092.1 DnaJ domain-containing protein -
M2903_RS13770 (M2903_13770) 34172..34588 + 417 WP_002368093.1 single-stranded DNA-binding protein -
M2903_RS13775 (M2903_13775) 34612..35196 + 585 WP_002368095.1 thermonuclease family protein -
M2903_RS13780 (M2903_13780) 35307..35573 + 267 WP_002369771.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M2903_RS13785 (M2903_13785) 35566..35841 + 276 WP_002360769.1 type II toxin-antitoxin system YafQ family toxin Toxin
M2903_RS13790 (M2903_13790) 36644..36829 + 186 WP_002368099.1 hypothetical protein -
M2903_RS13795 (M2903_13795) 36814..37005 + 192 WP_002401572.1 DpnD/PcfM family protein -
M2903_RS13800 (M2903_13800) 37236..38015 + 780 WP_002368102.1 Cas9 inhibitor AcrIIA9 family protein -
M2903_RS13805 (M2903_13805) 38015..39274 + 1260 WP_002368103.1 PcfJ domain-containing protein -
M2903_RS13810 (M2903_13810) 39924..40652 + 729 WP_002368105.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - asa1 1..76911 76911


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(7-86)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10732.58 Da        Isoelectric Point: 9.6918

>T244631 WP_002360769.1 NZ_CP097057:35566-35841 [Enterococcus faecalis]
MLEIFYTNQFKKDFKKAKKQGKNLEKLKEVLVLLQEQQTLPPKYKDHALTGNYIGTRECHIEPDWLLIYKIDGDKLILTL
ARIGSHSELFR

Download         Length: 276 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9772.09 Da        Isoelectric Point: 4.4791

>AT244631 WP_002369771.1 NZ_CP097057:35307-35573 [Enterococcus faecalis]
VATTKKKPIHVNVDENLKEEAEQLFDDLGLNMTSAITIFLKQSINEQAIPFMINKGNKETLQALKDIKEGNVHGGFSSVE
DLMEDLNA

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2AEA7

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AED7

References