Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2729828..2730399 Replicon chromosome
Accession NZ_CP097056
Organism Enterococcus faecalis strain AT09

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag M2903_RS13140 Protein ID WP_174114068.1
Coordinates 2729828..2730169 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID R3JGB1
Locus tag M2903_RS13145 Protein ID WP_002354773.1
Coordinates 2730169..2730399 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2903_RS13135 (2725843) 2725843..2729457 - 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -
M2903_RS13140 (2729828) 2729828..2730169 - 342 WP_174114068.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
M2903_RS13145 (2730169) 2730169..2730399 - 231 WP_002354773.1 hypothetical protein Antitoxin
M2903_RS13150 (2730814) 2730814..2731029 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
M2903_RS13155 (2731168) 2731168..2732160 + 993 WP_002378862.1 biotin--[acetyl-CoA-carboxylase] ligase -
M2903_RS13160 (2732327) 2732327..2732965 - 639 WP_002378863.1 lytic polysaccharide monooxygenase -
M2903_RS13165 (2733651) 2733651..2735267 + 1617 WP_174114069.1 phosphatase PAP2/LCP family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13177.42 Da        Isoelectric Point: 8.8678

>T244621 WP_174114068.1 NZ_CP097056:c2730169-2729828 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPIISTIKNIPTRYTLPDDIETHGQVVISQ
LQSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.67 Da        Isoelectric Point: 4.3313

>AT244621 WP_002354773.1 NZ_CP097056:c2730399-2730169 [Enterococcus faecalis]
MLTTKSRRQGSSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2A812

References