Detailed information of TA system TA024462

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 3674751..3675276
• Replicon: chromosome
• Accession: NC_013592
• Organism: Dickeya dadantii Ech586

Toxin (Protein)

• Gene name: relE
• Uniprot ID: D2BUZ5
• Locus tag: DD586_RS16025
• Protein ID: WP_012885867.1
• Coordinates: 3674751..3675035 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: DD586_RS16030
• Protein ID: WP_012885868.1
• Coordinates: 3675025..3675276 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DD586_RS16010	3670794..3671558	+	765	WP_012885864.1	SDR family oxidoreductase	-
DD586_RS16015	3671584..3672471	+	888	WP_012885865.1	methylated-DNA--[protein]-cysteine S-methyltransferase	-
DD586_RS16020	3672486..3673694	-	1209	WP_041164569.1	MFS transporter	-
DD586_RS16025	3674751..3675035	-	285	WP_012885867.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DD586_RS16030	3675025..3675276	-	252	WP_012885868.1	prevent-host-death protein	Antitoxin
DD586_RS16035	3675450..3675665	-	216	WP_012885869.1	hypothetical protein	-
DD586_RS21875	3675658..3675852	-	195	WP_041164570.1	host cell division inhibitor Icd-like protein	-
DD586_RS21880	3675852..3676069	-	218	Protein_3170	ash family protein	-
DD586_RS16045	3676792..3679224	+	2433	WP_012885870.1	type III-A CRISPR-associated protein Cas10/Csm1	-
DD586_RS16050	3679249..3679647	+	399	WP_012885871.1	type III-A CRISPR-associated protein Csm2	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10961.93 Da
• Isoelectric Point: 10.3350

>T24462 WP_012885867.1 NC_013592:c3675035-3674751 [Dickeya zeae Ech586]
MSYKLEFEEHALKEFKKLGAPVREQFIKKLKEVLQNPHIPANRLHGMADCYKIKLRSAGYRLVYHVLEHEIVVLVVAVGK
RERSQVYTSAKSRL

Nucleotide

• Length: 285 bp

>T24462 NC_013592:c3675035-3674751 [Dickeya zeae Ech586]
ATGAGTTATAAGCTGGAGTTTGAAGAGCACGCCCTGAAAGAGTTTAAGAAACTGGGTGCCCCGGTGCGGGAACAGTTCAT
CAAAAAGCTGAAAGAGGTGCTGCAAAACCCGCATATTCCCGCCAACCGGCTGCACGGCATGGCGGACTGCTACAAAATCA
AACTGCGATCCGCAGGCTACCGGCTGGTGTATCACGTGCTTGAGCATGAGATTGTGGTGCTGGTTGTGGCGGTGGGCAAA
CGAGAGCGCTCGCAGGTGTATACATCAGCCAAAAGCCGGCTTTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9036.42 Da
• Isoelectric Point: 7.2005

>AT24462 WP_012885868.1 NC_013592:c3675276-3675025 [Dickeya zeae Ech586]
MPVQPILANAAVSISEFKKSPNAALKAAHGEPVAVLTNGHISGYYVSPEIWETLADYLEDKELASIARSRMKGKRVKVTL
DEL

Nucleotide

• Length: 252 bp

>AT24462 NC_013592:c3675276-3675025 [Dickeya zeae Ech586]
ATGCCTGTACAACCCATTCTGGCGAATGCTGCCGTTAGCATCAGCGAGTTTAAAAAATCCCCCAATGCGGCACTGAAAGC
GGCACACGGCGAGCCTGTCGCGGTGTTAACCAATGGCCATATCTCGGGGTATTACGTTTCTCCCGAAATCTGGGAAACGC
TGGCCGACTATCTGGAAGACAAAGAACTTGCCAGCATCGCCCGTTCACGCATGAAGGGGAAACGCGTCAAGGTCACACTG
GATGAGTTATAA

Structures

Toxin

• AlphaFold DB: D2BUZ5