244603

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_19(antitoxin)
Location 129641..130660 Replicon chromosome
Accession NZ_CP097056
Organism Enterococcus faecalis strain AT09

Toxin (Protein)


Gene name IrrE Uniprot ID Q839N5
Locus tag M2903_RS00540 Protein ID WP_002359283.1
Coordinates 129641..130279 (-) Length 213 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag M2903_RS00545 Protein ID WP_002359284.1
Coordinates 130286..130660 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2903_RS00515 (125531) 125531..126496 + 966 WP_174113897.1 ornithine cyclodeaminase family protein -
M2903_RS00520 (126498) 126498..127286 + 789 WP_174113896.1 PhzF family phenazine biosynthesis protein -
M2903_RS00525 (127334) 127334..127879 - 546 WP_002385445.1 ATP:cob(I)alamin adenosyltransferase -
M2903_RS00530 (128030) 128030..128371 - 342 WP_174113895.1 hypothetical protein -
M2903_RS00535 (129024) 129024..129599 + 576 WP_002359282.1 restriction endonuclease -
M2903_RS00540 (129641) 129641..130279 - 639 WP_002359283.1 ImmA/IrrE family metallo-endopeptidase Toxin
M2903_RS00545 (130286) 130286..130660 - 375 WP_002359284.1 helix-turn-helix domain-containing protein Antitoxin
M2903_RS00550 (131502) 131502..131684 - 183 WP_002359286.1 hypothetical protein -
M2903_RS00555 (131851) 131851..132102 + 252 WP_002359287.1 hypothetical protein -
M2903_RS00560 (132189) 132189..132515 + 327 WP_002359288.1 hypothetical protein -
M2903_RS00565 (132515) 132515..132922 + 408 WP_002359289.1 DUF961 family protein -
M2903_RS00570 (133072) 133072..133296 + 225 WP_002359290.1 hypothetical protein -
M2903_RS00575 (133325) 133325..133516 + 192 WP_010773668.1 hypothetical protein -
M2903_RS00580 (133498) 133498..133902 + 405 WP_002359292.1 hypothetical protein -
M2903_RS00585 (134014) 134014..134346 + 333 WP_002359293.1 nucleotidyltransferase domain-containing protein -
M2903_RS00590 (134336) 134336..134719 + 384 WP_002359294.1 DUF86 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - EF0149 / tufA 119878..200364 80486


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(86-176)

Antitoxin

Cro/C1-type helix-turn-helix domain

(7-61)


Sequences

Toxin        


Download         Length: 213 a.a.        Molecular weight: 25186.21 Da        Isoelectric Point: 9.1676

>T244603 WP_002359283.1 NZ_CP097056:c130279-129641 [Enterococcus faecalis]
MILNKKKLYFETQAFTDKLINEISINMSKRKELINCYDIEAYVKETENIDFFDYPFKKQSKKLIWGSVTKIGDVTMVATA
QHLKIEIKNFTKMHEIIHHYFDYTTDMPNNEKSFDTLLIKKGYLPEDYPKEFRANKGAGMLLINKKALKYAFSTYDDLEK
MASFFNVNDIVLKIRILDELIYSHNLSYKQANLIYNSYYFQQQTQLKEILLK

Download         Length: 639 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14518.29 Da        Isoelectric Point: 4.8896

>AT244603 WP_002359284.1 NZ_CP097056:c130660-130286 [Enterococcus faecalis]
MKTYEKIKQLRENREITQKEISNALDINVSVYNKIELGIRPLREEELTAIADFFNVSIDYLTGRTDNPTTPSNNQKEAGQ
NIISHFRLNTNDLSSDDIEELEKELIDFQEFLIKRAKERKKKSE

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A059N6D0

Antitoxin

Source ID Structure

References