Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 868..1361 Replicon plasmid pAT19-a
Accession NZ_CP097052
Organism Vagococcus lutrae strain AT19

Toxin (Protein)


Gene name relE Uniprot ID V6Q3V2
Locus tag M2905_RS09575 Protein ID WP_023606340.1
Coordinates 868..1143 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V6Q580
Locus tag M2905_RS09580 Protein ID WP_023606341.1
Coordinates 1140..1361 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2905_RS09570 (M2905_09570) 137..745 + 609 WP_248857190.1 helix-turn-helix transcriptional regulator -
M2905_RS09575 (M2905_09575) 868..1143 - 276 WP_023606340.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M2905_RS09580 (M2905_09580) 1140..1361 - 222 WP_023606341.1 DUF6290 family protein Antitoxin
M2905_RS09585 (M2905_09585) 2866..3828 - 963 WP_248857191.1 Abi family protein -
M2905_RS09590 (M2905_09590) 4080..4616 - 537 WP_248857192.1 hypothetical protein -
M2905_RS09595 (M2905_09595) 4623..5372 - 750 WP_172442040.1 replication initiation protein -
M2905_RS09600 (M2905_09600) 5726..6289 - 564 WP_248857188.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..8573 8573


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-90)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10753.42 Da        Isoelectric Point: 10.4608

>T244602 WP_023606340.1 NZ_CP097052:c1143-868 [Vagococcus lutrae]
MTQKKYTVRYEKNAQKALKKMDKHQAGLIMSWISKNLNETEFPRHHGKALAGNKSGQWRYRVGDYRIIAHIDDDTITILV
LEIGHRREIYK

Download         Length: 276 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8357.54 Da        Isoelectric Point: 4.2925

>AT244602 WP_023606341.1 NZ_CP097052:c1361-1140 [Vagococcus lutrae]
MSNVTFRVTDEEKKFMQSMAELNGLSLSELARTKLLEALEDQIDIGLYEKAMKAHELKDESISHEEMLQELGL

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6Q3V2

Antitoxin

Source ID Structure
AlphaFold DB V6Q580

References