Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 11611..12107 Replicon plasmid pAT22-a
Accession NZ_CP097049
Organism Enterococcus faecalis strain AT22

Toxin (Protein)


Gene name relE Uniprot ID R3GZA4
Locus tag M2906_RS13910 Protein ID WP_002358470.1
Coordinates 11611..11880 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R3JPM7
Locus tag M2906_RS13915 Protein ID WP_002413218.1
Coordinates 11880..12107 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2906_RS13905 (M2906_13855) 9964..11544 - 1581 WP_002404189.1 DUF3991 domain-containing protein -
M2906_RS13910 (M2906_13860) 11611..11880 - 270 WP_002358470.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M2906_RS13915 (M2906_13865) 11880..12107 - 228 WP_002413218.1 DUF6290 family protein Antitoxin
M2906_RS13920 (M2906_13870) 12167..13402 - 1236 WP_010715713.1 MobP2 family relaxase -
M2906_RS13925 (M2906_13875) 13405..13962 - 558 WP_010785147.1 hypothetical protein -
M2906_RS13930 (M2906_13880) 13955..14218 - 264 WP_002358468.1 hypothetical protein -
M2906_RS13935 (M2906_13885) 14637..15461 - 825 WP_048941218.1 hypothetical protein -
M2906_RS13940 (M2906_13890) 15476..16000 - 525 WP_002358238.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - asa1 1..58872 58872


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10610.17 Da        Isoelectric Point: 10.5395

>T244601 WP_002358470.1 NZ_CP097049:c11880-11611 [Enterococcus faecalis]
MSYRLEFTPDVKKQLKKMDKYQATLLTRWLYRNIDGTANPREHGKALSANRAGQWRYRIGNYRVIVEIEDERLVVTAIQV
GHRRNVYDK

Download         Length: 270 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8785.90 Da        Isoelectric Point: 4.0179

>AT244601 WP_002413218.1 NZ_CP097049:c12107-11880 [Enterococcus faecalis]
MAMITVRVSDEEKEWLSYMAEFFGVTLSDLLKSYSMEQLEDEYDKQTAEIAHKRWIEQGKETISMDEILNEFGGL

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R3GZA4

Antitoxin

Source ID Structure
AlphaFold DB R3JPM7

References