244594

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2746896..2747467 Replicon chromosome
Accession NZ_CP097048
Organism Enterococcus faecalis strain AT22

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag M2906_RS13205 Protein ID WP_010710856.1
Coordinates 2746896..2747237 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID R3JGB1
Locus tag M2906_RS13210 Protein ID WP_002354773.1
Coordinates 2747237..2747467 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2906_RS13200 (2742911) 2742911..2746525 - 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -
M2906_RS13205 (2746896) 2746896..2747237 - 342 WP_010710856.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
M2906_RS13210 (2747237) 2747237..2747467 - 231 WP_002354773.1 hypothetical protein Antitoxin
M2906_RS13215 (2747798) 2747798..2748013 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
M2906_RS13220 (2748152) 2748152..2749144 + 993 WP_002394775.1 biotin--[acetyl-CoA-carboxylase] ligase -
M2906_RS13225 (2749311) 2749311..2749949 - 639 WP_002378863.1 lytic polysaccharide monooxygenase -
M2906_RS13230 (2750634) 2750634..2752250 + 1617 WP_010710855.1 phosphatase PAP2/LCP family protein -
- (2752334) 2752334..2752409 - 76 NuclAT_7 - -
- (2752307) 2752307..2752423 - 117 NuclAT_10 - -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13177.47 Da        Isoelectric Point: 9.3988

>T244594 WP_010710856.1 NZ_CP097048:c2747237-2746896 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPIISTIKNIPTRYTLPDDIETHGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.67 Da        Isoelectric Point: 4.3313

>AT244594 WP_002354773.1 NZ_CP097048:c2747467-2747237 [Enterococcus faecalis]
MLTTKSRRQGSSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2A812

References