Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2656743..2657314 Replicon chromosome
Accession NZ_CP097042
Organism Enterococcus faecalis strain AT34

Toxin (Protein)


Gene name mazF Uniprot ID R3GRA7
Locus tag M2910_RS12530 Protein ID WP_002360937.1
Coordinates 2656743..2657084 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID R3JGB1
Locus tag M2910_RS12535 Protein ID WP_002354773.1
Coordinates 2657084..2657314 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2910_RS12525 (2652758) 2652758..2656372 - 3615 WP_010712913.1 DNA-directed RNA polymerase subunit beta -
M2910_RS12530 (2656743) 2656743..2657084 - 342 WP_002360937.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
M2910_RS12535 (2657084) 2657084..2657314 - 231 WP_002354773.1 hypothetical protein Antitoxin
M2910_RS12540 (2657488) 2657488..2657703 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
M2910_RS12545 (2657842) 2657842..2658834 + 993 WP_002358973.1 biotin--[acetyl-CoA-carboxylase] ligase -
M2910_RS12550 (2659138) 2659138..2659776 - 639 WP_002375448.1 lytic polysaccharide monooxygenase -
M2910_RS12555 (2660463) 2660463..2662079 + 1617 WP_002372620.1 phosphatase PAP2/LCP family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13165.41 Da        Isoelectric Point: 9.3988

>T244552 WP_002360937.1 NZ_CP097042:c2657084-2656743 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETHGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.67 Da        Isoelectric Point: 4.3313

>AT244552 WP_002354773.1 NZ_CP097042:c2657314-2657084 [Enterococcus faecalis]
MLTTKSRRQGSSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2A7G9

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2A812

References