244532

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2711771..2712342 Replicon chromosome
Accession NZ_CP097038
Organism Enterococcus faecalis strain AT39

Toxin (Protein)


Gene name mazF Uniprot ID R3GRA7
Locus tag M2911_RS12875 Protein ID WP_002360937.1
Coordinates 2711771..2712112 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID R3JGB1
Locus tag M2911_RS12880 Protein ID WP_002354773.1
Coordinates 2712112..2712342 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2911_RS12870 (2707786) 2707786..2711400 - 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -
M2911_RS12875 (2711771) 2711771..2712112 - 342 WP_002360937.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
M2911_RS12880 (2712112) 2712112..2712342 - 231 WP_002354773.1 hypothetical protein Antitoxin
M2911_RS12885 (2712516) 2712516..2712731 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
M2911_RS12890 (2712870) 2712870..2713862 + 993 WP_002358973.1 biotin--[acetyl-CoA-carboxylase] ligase -
M2911_RS12895 (2713929) 2713929..2714561 - 633 WP_002358972.1 RloB family protein -
M2911_RS12900 (2714570) 2714570..2715865 - 1296 WP_248882009.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13165.41 Da        Isoelectric Point: 9.3988

>T244532 WP_002360937.1 NZ_CP097038:c2712112-2711771 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETHGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.67 Da        Isoelectric Point: 4.3313

>AT244532 WP_002354773.1 NZ_CP097038:c2712342-2712112 [Enterococcus faecalis]
MLTTKSRRQGSSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2A7G9

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2A812

References