Detailed information of TA system TA024453

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 1641750..1642303
• Replicon: chromosome
• Accession: NC_013592
• Organism: Dickeya dadantii Ech586

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: D2BWS9
• Locus tag: DD586_RS07180
• Protein ID: WP_012884147.1
• Coordinates: 1641989..1642303 (+)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: D2BWS8
• Locus tag: DD586_RS07175
• Protein ID: WP_012884146.1
• Coordinates: 1641750..1641986 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DD586_RS07165	1637575..1639884	-	2310	WP_012884145.1	TerB N-terminal domain-containing protein	-
DD586_RS07170	1640485..1641429	+	945	Protein_1417	DUF1738 domain-containing protein	-
DD586_RS07175	1641750..1641986	+	237	WP_012884146.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
DD586_RS07180	1641989..1642303	+	315	WP_012884147.1	CcdB family protein	Toxin
DD586_RS07185	1642300..1642561	-	262	Protein_1420	mobilization protein mobC	-
DD586_RS07190	1642934..1643437	+	504	WP_012884148.1	SMI1/KNR4 family protein	-
DD586_RS07195	1643475..1645013	+	1539	WP_012884149.1	hypothetical protein	-
DD586_RS07200	1645024..1646046	+	1023	WP_012884150.1	hypothetical protein	-
DD586_RS07205	1646239..1646985	-	747	WP_012884151.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	hcp / vgrG1	1507162..1670096	162934

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-103)

Antitoxin

• Post-segregation antitoxin CcdA (9-78)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 11514.46 Da
• Isoelectric Point: 7.9859

>T24453 WP_012884147.1 NC_013592:1641989-1642303 [Dickeya zeae Ech586]
MQFTIYGNTGKSAVYPLLLDVTSDIIGQLNRRIVIPLLPIEKYPAGRRPERLVPVVRLTDGKEYAVMTHELASIPVQALG
AVFCDASQYRNQVKAAIDFLIDGI

Nucleotide

• Length: 315 bp

>T24453 NC_013592:1641989-1642303 [Dickeya zeae Ech586]
ATGCAATTCACCATATACGGTAATACCGGGAAAAGCGCCGTTTACCCGCTGTTGCTCGATGTCACAAGCGATATTATTGG
GCAGTTAAATCGTCGGATAGTGATCCCGTTGCTCCCTATTGAAAAGTACCCGGCAGGCCGCCGACCGGAGCGCCTTGTCC
CCGTCGTCAGGCTGACGGACGGCAAAGAATACGCCGTAATGACGCACGAGCTGGCAAGTATCCCTGTGCAGGCGTTGGGT
GCGGTGTTCTGTGATGCGTCGCAGTACCGTAATCAGGTAAAGGCCGCAATAGATTTCCTCATTGACGGCATTTAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9062.10 Da
• Isoelectric Point: 6.4629

>AT24453 WP_012884146.1 NC_013592:1641750-1641986 [Dickeya zeae Ech586]
MTAKQRNTQSVTMTVERALLVRAREAGINLSATLSTALDAELRRYEAKKWQEENREAIDALNRFHDEHGCFSDEYRTF

Nucleotide

• Length: 237 bp

>AT24453 NC_013592:1641750-1641986 [Dickeya zeae Ech586]
ATGACCGCGAAACAACGTAACACGCAGAGCGTGACCATGACGGTAGAGCGTGCCTTACTGGTCCGGGCGCGTGAAGCGGG
CATTAACCTGAGTGCCACGCTGTCAACCGCACTGGATGCGGAGCTTCGCCGTTATGAGGCGAAAAAATGGCAGGAAGAGA
ACAGGGAAGCCATCGACGCATTAAATCGTTTTCATGATGAGCACGGCTGTTTCAGTGACGAATACAGGACGTTTTAA

Structures

Toxin

• AlphaFold DB: D2BWS9

Antitoxin

• AlphaFold DB: D2BWS8