Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 34735..35872 Replicon plasmid pAT40b-a
Accession NZ_CP097035
Organism Enterococcus faecalis strain AT40b

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag M2913_RS13650 Protein ID WP_248878840.1
Coordinates 34735..35598 (-) Length 288 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID Q9AL01
Locus tag M2913_RS13655 Protein ID WP_002331065.1
Coordinates 35600..35872 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2913_RS13620 (M2913_13620) 29750..31744 - 1995 WP_248878838.1 MobA/MobL family protein -
M2913_RS13625 (M2913_13625) 32027..32326 + 300 WP_002332653.1 hypothetical protein -
M2913_RS13630 (M2913_13630) 32329..32586 + 258 WP_000002668.1 hypothetical protein -
M2913_RS13635 (M2913_13635) 32680..32913 - 234 WP_002332654.1 hypothetical protein -
M2913_RS13640 (M2913_13640) 32947..33444 - 498 WP_002338758.1 hypothetical protein -
M2913_RS13645 (M2913_13645) 33978..34295 - 318 WP_002326830.1 hypothetical protein -
M2913_RS13650 (M2913_13650) 34735..35598 - 864 WP_248878840.1 zeta toxin family protein Toxin
M2913_RS13655 (M2913_13655) 35600..35872 - 273 WP_002331065.1 antitoxin Antitoxin
M2913_RS13660 (M2913_13660) 35889..36098 - 210 WP_000527318.1 peptide-binding protein -
M2913_RS13665 (M2913_13665) 36197..37093 - 897 WP_002334978.1 AAA family ATPase -
M2913_RS13670 (M2913_13670) 37196..39340 - 2145 WP_248878842.1 type IA DNA topoisomerase -
M2913_RS13675 (M2913_13675) 39340..39957 - 618 WP_001062587.1 recombinase family protein -
M2913_RS13680 (M2913_13680) 39971..40141 - 171 WP_000713595.1 hypothetical protein -
M2913_RS13685 (M2913_13685) 40497..40713 - 217 Protein_42 PadR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..92441 92441


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(28-214)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 288 a.a.        Molecular weight: 32598.15 Da        Isoelectric Point: 6.9969

>T244522 WP_248878840.1 NZ_CP097035:c35598-34735 [Enterococcus faecalis]
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAIFEETQGNVIVIDNDTFKQQHPNFDELV
KLYEKDVVKHVTPYSNRMTEALISRLSDQGYNLVIEGTGRTTDVPIQTATMLQSKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMVQNQHQETPEFKAIQQKMESLQPPTPPIPKTPKLPGI

Download         Length: 864 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10733.17 Da        Isoelectric Point: 4.4865

>AT244522 WP_002331065.1 NZ_CP097035:c35872-35600 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYS
KQILNKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZL55

References