Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1162758..1163383 Replicon chromosome
Accession NC_013592
Organism Dickeya dadantii Ech586

Toxin (Protein)


Gene name Hha Uniprot ID E0SD87
Locus tag DD586_RS05240 Protein ID WP_009114000.1
Coordinates 1162758..1162961 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID D2BUK3
Locus tag DD586_RS05245 Protein ID WP_012883774.1
Coordinates 1163015..1163383 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DD586_RS05215 1158380..1158718 + 339 WP_002208627.1 P-II family nitrogen regulator -
DD586_RS05220 1158762..1160054 + 1293 WP_012883770.1 ammonium transporter AmtB -
DD586_RS05225 1160178..1161041 - 864 WP_012883771.1 acyl-CoA thioesterase II -
DD586_RS05230 1161259..1161840 + 582 WP_012883772.1 YbaY family lipoprotein -
DD586_RS05235 1161881..1162207 - 327 WP_012883773.1 MGMT family protein -
DD586_RS05240 1162758..1162961 - 204 WP_009114000.1 hemolysin expression modulator Hha Toxin
DD586_RS05245 1163015..1163383 - 369 WP_012883774.1 Hha toxicity modulator TomB Antitoxin
DD586_RS21235 1163893..1164036 - 144 WP_012883775.1 type B 50S ribosomal protein L36 -
DD586_RS05250 1164052..1164303 - 252 WP_012883776.1 type B 50S ribosomal protein L31 -
DD586_RS05255 1164479..1167625 - 3147 WP_012883777.1 multidrug efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8133.51 Da        Isoelectric Point: 8.8500

>T24452 WP_009114000.1 NC_013592:c1162961-1162758 [Dickeya zeae Ech586]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFYSAADHRLAELTMNKLYDKVPTAVWKYVR

Download         Length: 204 bp

>T24452 NC_013592:c1162961-1162758 [Dickeya zeae Ech586]
ATGAAAAAAATCGACTATTTAATGCGTTTGCGTAAATGTACAACCATCGACACGCTTGAGCGTGTTATAGAAAAAAACAA
GTACGAGCTTTCTAACGACGAACTTGAAATGTTCTATTCAGCTGCCGACCATCGTCTGGCTGAGCTAACGATGAATAAAC
TTTACGACAAAGTGCCAACTGCCGTATGGAAATATGTTCGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14186.04 Da        Isoelectric Point: 5.1811

>AT24452 WP_012883774.1 NC_013592:c1163383-1163015 [Dickeya zeae Ech586]
MDEYTPQHYDIAQLRFLCENLHDESIATLGDSSRGWVNDPTSAVNLQLNELIEHIAAFVVTYKIKYPHEAALCERVEKYL
DDTYILFSNYGINDSELQKWKKSKSQLFRMFSEKSVCTVVKT

Download         Length: 369 bp

>AT24452 NC_013592:c1163383-1163015 [Dickeya zeae Ech586]
ATGGATGAGTACACACCTCAACATTATGATATTGCCCAACTCAGATTCTTGTGTGAAAATCTGCACGACGAAAGTATCGC
AACATTAGGTGACAGCAGTCGTGGCTGGGTGAATGATCCGACCTCTGCGGTCAATCTTCAACTAAACGAACTTATCGAAC
ACATTGCGGCATTTGTTGTTACCTACAAAATAAAATATCCGCATGAAGCGGCGCTGTGTGAGCGGGTTGAAAAATACCTG
GACGATACTTATATTCTTTTCAGCAACTACGGTATAAATGATTCAGAGTTGCAGAAATGGAAAAAATCCAAGTCGCAATT
ATTCAGAATGTTCTCAGAAAAGAGCGTCTGTACGGTAGTAAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X3RNQ0

Antitoxin

Source ID Structure
AlphaFold DB A0A2K9QCC2

References