244517

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2675007..2675578 Replicon chromosome
Accession NZ_CP097034
Organism Enterococcus faecalis strain AT40b

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag M2913_RS13000 Protein ID WP_002354774.1
Coordinates 2675007..2675348 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID R3JGB1
Locus tag M2913_RS13005 Protein ID WP_002354773.1
Coordinates 2675348..2675578 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2913_RS12995 (2671022) 2671022..2674636 - 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -
M2913_RS13000 (2675007) 2675007..2675348 - 342 WP_002354774.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
M2913_RS13005 (2675348) 2675348..2675578 - 231 WP_002354773.1 hypothetical protein Antitoxin
M2913_RS13010 (2675752) 2675752..2675967 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
M2913_RS13015 (2676106) 2676106..2677098 + 993 WP_002378862.1 biotin--[acetyl-CoA-carboxylase] ligase -
M2913_RS13020 (2677265) 2677265..2677903 - 639 WP_002378863.1 lytic polysaccharide monooxygenase -
M2913_RS13025 (2678588) 2678588..2680204 + 1617 WP_002378864.1 phosphatase PAP2/LCP family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13156.40 Da        Isoelectric Point: 9.3984

>T244517 WP_002354774.1 NZ_CP097034:c2675348-2675007 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETQGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.67 Da        Isoelectric Point: 4.3313

>AT244517 WP_002354773.1 NZ_CP097034:c2675578-2675348 [Enterococcus faecalis]
MLTTKSRRQGSSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2A812

References