Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Xre-MNT/HTH_26(antitoxin)
Location 1378700..1379808 Replicon chromosome
Accession NZ_CP097034
Organism Enterococcus faecalis strain AT40b

Toxin (Protein)


Gene name MNTss Uniprot ID A0A193AUR0
Locus tag M2913_RS06680 Protein ID WP_002378351.1
Coordinates 1378700..1379569 (-) Length 290 a.a.

Antitoxin (Protein)


Gene name Xress Uniprot ID -
Locus tag M2913_RS06685 Protein ID WP_000205227.1
Coordinates 1379584..1379808 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2913_RS06660 (1374971) 1374971..1376290 - 1320 WP_002338419.1 IS1380-like element ISSsu5 family transposase -
M2913_RS06665 (1376518) 1376518..1377045 - 528 WP_002294507.1 phosphoribosyltransferase family protein -
M2913_RS06670 (1377089) 1377089..1377952 - 864 WP_002294505.1 aminoglycoside nucleotidyltransferase ANT(6)-Ia -
M2913_RS06675 (1377985) 1377985..1378719 - 735 WP_000662263.1 class I SAM-dependent methyltransferase -
M2913_RS06680 (1378700) 1378700..1379569 - 870 WP_002378351.1 nucleotidyltransferase domain-containing protein Toxin
M2913_RS06685 (1379584) 1379584..1379808 - 225 WP_000205227.1 helix-turn-helix transcriptional regulator Antitoxin
M2913_RS06690 (1379951) 1379951..1380037 - 87 Protein_1287 site-specific recombinase -
M2913_RS06695 (1380226) 1380226..1381527 + 1302 Protein_1288 ISL3 family transposase -
M2913_RS06700 (1381836) 1381836..1382639 - 804 WP_002294514.1 lincosamide nucleotidyltransferase Lnu(B) -
M2913_RS06705 (1382693) 1382693..1384177 - 1485 WP_002294513.1 ABC-F type ribosomal protection protein Lsa(E) -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn erm(B) / ant(6)-Ia / lnu(B) / lsa(E) / aph(3')-III / aac(6')-aph(2'') - 1367649..1398012 30363
- inside Genomic island ant(6)-Ia / lnu(B) / lsa(E) / aph(3')-III / aac(6')-aph(2'') - 1377089..1393399 16310


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polymerase, nucleotidyl transferase domain

(12-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(4-57)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 32912.50 Da        Isoelectric Point: 4.7903

>T244513 WP_002378351.1 NZ_CP097034:c1379569-1378700 [Enterococcus faecalis]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDKNRNNLVVPPGAWGDW
INGGGWLFINGYHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGVEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYNEVNEIVSEINNFLNEESSDERKQI

Download         Length: 870 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8365.68 Da        Isoelectric Point: 4.5510

>AT244513 WP_000205227.1 NZ_CP097034:c1379808-1379584 [Enterococcus faecalis]
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGEEIKISNE

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A193AUR0

Antitoxin

Source ID Structure

References