Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 1369128..1370265 Replicon chromosome
Accession NZ_CP097034
Organism Enterococcus faecalis strain AT40b

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag M2913_RS06615 Protein ID WP_002401483.1
Coordinates 1369128..1369991 (-) Length 288 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID R2XCR7
Locus tag M2913_RS06620 Protein ID WP_000301765.1
Coordinates 1369993..1370265 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2913_RS06585 (1364599) 1364599..1365462 - 864 WP_002382350.1 DNA-processing protein DprA -
M2913_RS06590 (1365523) 1365523..1366290 - 768 WP_002357481.1 ribonuclease HII -
M2913_RS06595 (1366292) 1366292..1367143 - 852 WP_002357480.1 ribosome biogenesis GTPase YlqF -
M2913_RS06600 (1367419) 1367419..1367592 - 174 Protein_1269 ketopantoate reductase C-terminal domain-containing protein -
M2913_RS06605 (1367649) 1367649..1368329 - 681 WP_010710189.1 IS6-like element IS1216 family transposase -
M2913_RS06610 (1368403) 1368403..1368690 - 288 Protein_1271 DnaJ domain-containing protein -
M2913_RS06615 (1369128) 1369128..1369991 - 864 WP_002401483.1 zeta toxin family protein Toxin
M2913_RS06620 (1369993) 1369993..1370265 - 273 WP_000301765.1 antitoxin Antitoxin
M2913_RS06625 (1370282) 1370282..1370497 - 216 WP_002295735.1 peptide-binding protein -
M2913_RS06630 (1370596) 1370596..1371492 - 897 WP_002387620.1 ParA family protein -
M2913_RS06635 (1371595) 1371595..1371855 - 261 Protein_1276 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
M2913_RS06640 (1372025) 1372025..1372762 - 738 WP_002292226.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) -
M2913_RS06645 (1372887) 1372887..1372982 - 96 WP_001809736.1 23S rRNA methyltransferase attenuation leader peptide -
M2913_RS06650 (1373051) 1373051..1373173 - 123 Protein_1279 peptide-binding protein -
M2913_RS06655 (1373293) 1373293..1374819 - 1527 WP_025191980.1 type IA DNA topoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn erm(B) / ant(6)-Ia / lnu(B) / lsa(E) / aph(3')-III / aac(6')-aph(2'') - 1367649..1398012 30363


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-213)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 288 a.a.        Molecular weight: 32486.06 Da        Isoelectric Point: 6.9965

>T244512 WP_002401483.1 NZ_CP097034:c1369991-1369128 [Enterococcus faecalis]
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAILEETQGNVIVIDNDTFKQQHPNFDELA
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSRLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMLQNQHQETPEFKAIQQKMESLQPPTPPIPKTPKLPGL

Download         Length: 864 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10721.25 Da        Isoelectric Point: 6.4676

>AT244512 WP_000301765.1 NZ_CP097034:c1370265-1369993 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 3Q8X
PDB 1GVN
AlphaFold DB A0A829F0A3

References