Detailed information of TA system TA024451

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 706354..707032
• Replicon: chromosome
• Accession: NC_013592
• Organism: Dickeya dadantii Ech586

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: D2BSA8
• Locus tag: DD586_RS03225
• Protein ID: WP_012883372.1
• Coordinates: 706601..707032 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: DD586_RS03220
• Protein ID: WP_038906203.1
• Coordinates: 706354..706620 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DD586_RS03205	703516..704124	-	609	WP_012883368.1	HD domain-containing protein	-
DD586_RS03210	704337..704987	+	651	WP_038913159.1	hemolysin III family protein	-
DD586_RS03215	705065..706045	-	981	WP_012883370.1	tRNA-modifying protein YgfZ	-
DD586_RS03220	706354..706620	+	267	WP_038906203.1	FAD assembly factor SdhE	Antitoxin
DD586_RS03225	706601..707032	+	432	WP_012883372.1	protein YgfX	Toxin
DD586_RS03230	707121..707639	-	519	WP_012883373.1	flavodoxin FldB	-
DD586_RS03235	707805..709130	-	1326	WP_012883374.1	MHS family MFS transporter	-
DD586_RS03240	709394..710293	+	900	WP_012883375.1	site-specific tyrosine recombinase XerD	-
DD586_RS03245	710381..711097	+	717	WP_012883376.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 16887.54 Da
• Isoelectric Point: 11.5023

>T24451 WP_012883372.1 NC_013592:706601-707032 [Dickeya zeae Ech586]
VAQWQCDLRVSWRMQLFSLLTHGFLMLMILLAPWPDGYAPLWLGLVTLVVFDFVRSQRSIKSRQGEISLRGDNQLHWQQR
DWQIVRRPWFMRNGVLLSLRAVDGKGQQRLWLASDSMGSEEWRLLRQQLQQPALHGTESSRHH

Nucleotide

• Length: 432 bp

>T24451 NC_013592:706601-707032 [Dickeya zeae Ech586]
GTGGCCCAGTGGCAATGTGATTTACGCGTATCCTGGCGTATGCAGTTGTTTTCGCTGCTAACGCACGGATTTCTGATGCT
GATGATCCTGCTGGCTCCCTGGCCGGACGGCTACGCGCCGCTGTGGCTCGGGTTAGTGACGCTGGTCGTGTTTGACTTTG
TGCGTAGCCAGCGAAGCATCAAATCGCGCCAGGGTGAAATTTCCCTGCGTGGCGATAACCAACTGCACTGGCAGCAACGT
GACTGGCAGATTGTCCGGCGACCGTGGTTCATGCGCAATGGCGTATTATTATCGCTACGAGCGGTGGATGGTAAAGGGCA
ACAGCGTTTGTGGCTGGCGTCAGACAGTATGGGGAGTGAGGAATGGCGGCTGTTACGTCAACAGTTGCAGCAGCCTGCGC
TGCATGGAACGGAATCTTCCCGCCATCATTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10446.96 Da
• Isoelectric Point: 5.5981

>AT24451 WP_038906203.1 NC_013592:706354-706620 [Dickeya zeae Ech586]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDDKQQFIRLLQCDDPDLFNWLMNHGEPVDPGLKRMVSLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT24451 NC_013592:706354-706620 [Dickeya zeae Ech586]
ATGGACATCAATAACAAAGCACGTATTCACTGGGCGTGCAGGCGTGGAATGCGCGAACTGGACATCTCCATCATGCCGTT
TTTCGAGCATGAGTACGATACGCTGAGCGACGACGACAAGCAGCAGTTTATTCGCCTGCTGCAGTGTGATGATCCCGACC
TGTTTAATTGGTTGATGAACCACGGCGAGCCGGTTGATCCTGGTTTGAAGCGGATGGTTTCCCTTATTCAGACGCGAAAT
AAAGATCGTGGCCCAGTGGCAATGTGA

Structures

Toxin

• AlphaFold DB: A0A2K9QB06