244508

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 45906..46402 Replicon plasmid pAT41-b
Accession NZ_CP097033
Organism Enterococcus faecalis strain AT41

Toxin (Protein)


Gene name relE Uniprot ID R3GZA4
Locus tag M2914_RS13880 Protein ID WP_002358470.1
Coordinates 46133..46402 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R3JPM7
Locus tag M2914_RS13875 Protein ID WP_002413218.1
Coordinates 45906..46133 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2914_RS13850 (M2914_13850) 42013..42537 + 525 WP_002358238.1 hypothetical protein -
M2914_RS13855 (M2914_13855) 42552..43376 + 825 WP_010829868.1 hypothetical protein -
M2914_RS13860 (M2914_13860) 43795..44058 + 264 WP_002358468.1 hypothetical protein -
M2914_RS13865 (M2914_13865) 44051..44608 + 558 WP_002358242.1 hypothetical protein -
M2914_RS13870 (M2914_13870) 44611..45846 + 1236 WP_010717251.1 MobP2 family relaxase -
M2914_RS13875 (M2914_13875) 45906..46133 + 228 WP_002413218.1 DUF6290 family protein Antitoxin
M2914_RS13880 (M2914_13880) 46133..46402 + 270 WP_002358470.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M2914_RS13885 (M2914_13885) 46469..48049 + 1581 WP_248870298.1 DUF3991 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - asa1 1..57256 57256


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10610.17 Da        Isoelectric Point: 10.5395

>T244508 WP_002358470.1 NZ_CP097033:46133-46402 [Enterococcus faecalis]
MSYRLEFTPDVKKQLKKMDKYQATLLTRWLYRNIDGTANPREHGKALSANRAGQWRYRIGNYRVIVEIEDERLVVTAIQV
GHRRNVYDK

Download         Length: 270 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8785.90 Da        Isoelectric Point: 4.0179

>AT244508 WP_002413218.1 NZ_CP097033:45906-46133 [Enterococcus faecalis]
MAMITVRVSDEEKEWLSYMAEFFGVTLSDLLKSYSMEQLEDEYDKQTAEIAHKRWIEQGKETISMDEILNEFGGL

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R3GZA4

Antitoxin

Source ID Structure
AlphaFold DB R3JPM7

References