24449

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 469600..470127 Replicon chromosome
Accession NC_013592
Organism Dickeya dadantii Ech586

Toxin (Protein)


Gene name relE Uniprot ID D2C2R7
Locus tag DD586_RS02125 Protein ID WP_012883161.1
Coordinates 469852..470127 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D2C2R6
Locus tag DD586_RS02120 Protein ID WP_012883160.1
Coordinates 469600..469848 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DD586_RS02090 465509..466375 + 867 WP_012883155.1 GTPase family protein -
DD586_RS02095 466466..467287 + 822 WP_012883156.1 DUF945 domain-containing protein -
DD586_RS02100 467318..467791 + 474 WP_012768688.1 DNA repair protein RadC -
DD586_RS02105 467791..468192 + 402 WP_012883157.1 type IV toxin-antitoxin system YeeU family antitoxin -
DD586_RS02110 468218..468538 + 321 WP_012883158.1 TA system toxin CbtA family protein -
DD586_RS02115 468656..469489 + 834 WP_012883159.1 DUF4942 domain-containing protein -
DD586_RS02120 469600..469848 + 249 WP_012883160.1 ribbon-helix-helix domain-containing protein Antitoxin
DD586_RS02125 469852..470127 + 276 WP_012883161.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DD586_RS02130 470164..470559 + 396 WP_035339559.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein -
DD586_RS02135 471010..472449 + 1440 WP_041164247.1 sensor domain-containing diguanylate cyclase -
DD586_RS02140 472569..473294 - 726 WP_012883164.1 methyltransferase domain-containing protein -
DD586_RS02145 473708..474556 + 849 WP_012883165.1 pirin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 462842..481823 18981


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 11194.47 Da        Isoelectric Point: 5.1487

>T24449 WP_012883161.1 NC_013592:469852-470127 [Dickeya zeae Ech586]
MEILWTQKAQDDLERIYRFASQYSRQHADDVLDRLFIGTTELVDHPRIGVSQTRYEPREVRKILFDDYEVHYEIQHNTIY
IVDLWHTREDR

Download         Length: 276 bp

>T24449 NC_013592:469852-470127 [Dickeya zeae Ech586]
ATGGAAATACTTTGGACACAAAAGGCACAGGATGACCTAGAGCGCATTTATCGGTTTGCCAGCCAGTACAGTCGGCAGCA
TGCTGACGATGTGTTAGATCGCCTGTTCATCGGAACAACAGAGCTTGTTGATCATCCAAGAATCGGTGTATCTCAGACAA
GATATGAACCCCGTGAGGTGAGAAAAATTCTGTTTGATGATTACGAGGTTCACTATGAAATTCAGCACAACACTATTTAT
ATCGTCGATTTGTGGCATACACGAGAAGATCGCTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9020.34 Da        Isoelectric Point: 6.4653

>AT24449 WP_012883160.1 NC_013592:469600-469848 [Dickeya zeae Ech586]
MGQPAKQTISAQIPAELAAAVESLAIELDRSKSWVIKEALTAMIEERERQHQRILQGLADVDAGRVVNHADVLDFANKLK
KS

Download         Length: 249 bp

>AT24449 NC_013592:469600-469848 [Dickeya zeae Ech586]
ATGGGACAGCCCGCAAAACAGACTATTAGTGCTCAGATACCCGCCGAGCTTGCTGCTGCGGTTGAAAGCCTGGCTATTGA
ATTGGATAGGTCGAAAAGTTGGGTGATTAAAGAAGCATTGACCGCAATGATCGAAGAGAGAGAACGTCAGCATCAACGGA
TTTTGCAAGGCCTTGCTGATGTTGATGCTGGAAGGGTGGTAAACCATGCTGATGTTCTCGATTTTGCCAATAAACTGAAA
AAGTCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A375A6K4

Antitoxin

Source ID Structure
AlphaFold DB A0A375A6R5

References