Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2674223..2674794 Replicon chromosome
Accession NZ_CP097030
Organism Enterococcus faecalis strain AT43a

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag M2915_RS12680 Protein ID WP_002354774.1
Coordinates 2674223..2674564 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID R3JGB1
Locus tag M2915_RS12685 Protein ID WP_002354773.1
Coordinates 2674564..2674794 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2915_RS12675 (2670238) 2670238..2673852 - 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -
M2915_RS12680 (2674223) 2674223..2674564 - 342 WP_002354774.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
M2915_RS12685 (2674564) 2674564..2674794 - 231 WP_002354773.1 hypothetical protein Antitoxin
M2915_RS12690 (2675201) 2675201..2675416 - 216 WP_002358974.1 zinc ribbon domain-containing protein -
M2915_RS12695 (2675555) 2675555..2676547 + 993 WP_002358973.1 biotin--[acetyl-CoA-carboxylase] ligase -
M2915_RS12700 (2676614) 2676614..2677246 - 633 WP_002358972.1 RloB family protein -
M2915_RS12705 (2677255) 2677255..2678550 - 1296 WP_002396787.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13156.40 Da        Isoelectric Point: 9.3984

>T244461 WP_002354774.1 NZ_CP097030:c2674564-2674223 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETQGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.67 Da        Isoelectric Point: 4.3313

>AT244461 WP_002354773.1 NZ_CP097030:c2674794-2674564 [Enterococcus faecalis]
MLTTKSRRQGSSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2A812

References