244455

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Xre-MNT/HTH_26(antitoxin)
Location 100359..101467 Replicon plasmid pAT44-a
Accession NZ_CP097028
Organism Enterococcus faecium strain AT44

Toxin (Protein)


Gene name MNTss Uniprot ID R3JIN1
Locus tag M2916_RS13570 Protein ID WP_000233000.1
Coordinates 100359..101228 (-) Length 290 a.a.

Antitoxin (Protein)


Gene name Xress Uniprot ID -
Locus tag M2916_RS13575 Protein ID WP_000205227.1
Coordinates 101243..101467 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2916_RS13540 (M2916_13540) 95778..96515 - 738 WP_002321849.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) -
M2916_RS13545 (M2916_13545) 96640..96735 - 96 WP_001809736.1 23S rRNA methyltransferase attenuation leader peptide -
M2916_RS14310 96784..96867 - 84 Protein_107 MLS leader peptide -
M2916_RS13550 (M2916_13550) 97277..98071 - 795 WP_001096887.1 aminoglycoside O-phosphotransferase APH(3')-IIIa -
M2916_RS13555 (M2916_13555) 98164..98706 - 543 WP_000627290.1 streptothricin N-acetyltransferase Sat4 -
M2916_RS13560 (M2916_13560) 98703..99611 - 909 WP_001255866.1 aminoglycoside nucleotidyltransferase ANT(6)-Ia -
M2916_RS13565 (M2916_13565) 99644..100378 - 735 WP_000662263.1 class I SAM-dependent methyltransferase -
M2916_RS13570 (M2916_13570) 100359..101228 - 870 WP_000233000.1 nucleotidyltransferase domain-containing protein Toxin
M2916_RS13575 (M2916_13575) 101243..101467 - 225 WP_000205227.1 helix-turn-helix transcriptional regulator Antitoxin
M2916_RS13580 (M2916_13580) 101610..101839 - 230 Protein_114 hypothetical protein -
M2916_RS13585 (M2916_13585) 101905..103187 + 1283 Protein_115 ISL3 family transposase -
M2916_RS13590 (M2916_13590) 103496..104299 - 804 WP_002294514.1 lincosamide nucleotidyltransferase Lnu(B) -
M2916_RS13595 (M2916_13595) 104353..105837 - 1485 WP_002294513.1 ABC-F type ribosomal protection protein Lsa(E) -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polymerase, nucleotidyl transferase domain

(12-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(4-57)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 32926.57 Da        Isoelectric Point: 4.8781

>T244455 WP_000233000.1 NZ_CP097028:c101228-100359 [Enterococcus faecium]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDKNRNNLVVPPGAWGDW
INGGGWLFINGYHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGVEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYKEVNEIVSEINNFLNEESSDERKQI

Download         Length: 870 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8365.68 Da        Isoelectric Point: 4.5510

>AT244455 WP_000205227.1 NZ_CP097028:c101467-101243 [Enterococcus faecium]
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGEEIKISNE

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R3JIN1

Antitoxin

Source ID Structure

References