Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 475030..475601 Replicon chromosome
Accession NZ_CP097027
Organism Enterococcus faecium strain AT44

Toxin (Protein)


Gene name mazF Uniprot ID Q3Y2B8
Locus tag M2916_RS02285 Protein ID WP_002286801.1
Coordinates 475260..475601 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A828ZZN9
Locus tag M2916_RS02280 Protein ID WP_002323011.1
Coordinates 475030..475260 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2916_RS02255 (M2916_02255) 470511..471839 + 1329 WP_002327434.1 FAD-containing oxidoreductase -
M2916_RS02260 (M2916_02260) 471861..472487 + 627 WP_002286816.1 cysteine hydrolase -
M2916_RS02265 (M2916_02265) 472670..473251 + 582 WP_002327433.1 TetR/AcrR family transcriptional regulator -
M2916_RS02270 (M2916_02270) 473616..474191 + 576 WP_002352505.1 SOS response-associated peptidase family protein -
M2916_RS02275 (M2916_02275) 474396..474734 - 339 WP_002306002.1 hypothetical protein -
M2916_RS02280 (M2916_02280) 475030..475260 + 231 WP_002323011.1 hypothetical protein Antitoxin
M2916_RS02285 (M2916_02285) 475260..475601 + 342 WP_002286801.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
M2916_RS02290 (M2916_02290) 476451..476636 + 186 WP_002304207.1 hypothetical protein -
M2916_RS02295 (M2916_02295) 476906..478068 + 1163 WP_086956687.1 IS3 family transposase -
M2916_RS02300 (M2916_02300) 478199..478441 + 243 Protein_456 LPXTG cell wall anchor domain-containing protein -
M2916_RS02305 (M2916_02305) 478514..479410 + 897 Protein_457 class C sortase -
M2916_RS02310 (M2916_02310) 479591..480265 + 675 WP_038811248.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13302.68 Da        Isoelectric Point: 9.9044

>T244454 WP_002286801.1 NZ_CP097027:475260-475601 [Enterococcus faecium]
VSEERIYIPKKGDIVWIDFDPSVGKEIQKRRPGLVVSRYEFNRKTMFSVICPITSTIKNLPTRYSLPEELDIKGQVIITQ
LKSLDFKERKLKKIENLPLQDMAKIDQIIQYMF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8523.39 Da        Isoelectric Point: 3.9078

>AT244454 WP_002323011.1 NZ_CP097027:475030-475260 [Enterococcus faecium]
MLVTKSRLQGSSVVVTLPSDNGKKPSENQEYIVVYSDDGTITLVPKIEDPFSGGEEAEYYEKDEWEDLTPEGREIL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FD66

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZZN9

References