244453

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 183240..183769 Replicon chromosome
Accession NZ_CP097027
Organism Enterococcus faecium strain AT44

Toxin (Protein)


Gene name relE Uniprot ID A0A2D0BMD7
Locus tag M2916_RS00910 Protein ID WP_002319468.1
Coordinates 183503..183769 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C9B8W8
Locus tag M2916_RS00905 Protein ID WP_002294199.1
Coordinates 183240..183503 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2916_RS00895 (M2916_00895) 180615..182438 + 1824 WP_002294202.1 APC family permease -
M2916_RS00900 (M2916_00900) 182580..182765 - 186 WP_038811433.1 hypothetical protein -
M2916_RS00905 (M2916_00905) 183240..183503 + 264 WP_002294199.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
M2916_RS00910 (M2916_00910) 183503..183769 + 267 WP_002319468.1 Txe/YoeB family addiction module toxin Toxin
M2916_RS00915 (M2916_00915) 183970..184458 + 489 WP_002296561.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
M2916_RS00920 (M2916_00920) 185000..185671 - 672 WP_002319469.1 ABC transporter permease -
M2916_RS00925 (M2916_00925) 185668..186585 - 918 WP_002319470.1 osmoprotectant ABC transporter substrate-binding protein -
M2916_RS00930 (M2916_00930) 186582..187223 - 642 WP_002293405.1 ABC transporter permease -
M2916_RS00935 (M2916_00935) 187227..188402 - 1176 WP_002294192.1 betaine/proline/choline family ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(22-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10632.08 Da        Isoelectric Point: 9.9931

>T244453 WP_002319468.1 NZ_CP097027:183503-183769 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQTNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVAEI
YSAWTHYE

Download         Length: 267 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10016.03 Da        Isoelectric Point: 4.1207

>AT244453 WP_002294199.1 NZ_CP097027:183240-183503 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
DIDWEAL

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2D0BMD7

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZU84

References