Detailed information of TA system TA024445

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 182456..183087
• Replicon: chromosome
• Accession: NC_013530
• Organism: Xylanimonas cellulosilytica DSM 15894

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: XCEL_RS00765
• Protein ID: WP_012876936.1
• Coordinates: 182456..182860 (-)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: D1BU28
• Locus tag: XCEL_RS00770
• Protein ID: WP_012876937.1
• Coordinates: 182857..183087 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XCEL_RS00755	179893..181763	+	1871	Protein_148	ribonucleoside triphosphate reductase	-
XCEL_RS00760	181756..182454	+	699	WP_012876935.1	anaerobic ribonucleoside-triphosphate reductase activating protein	-
XCEL_RS00765	182456..182860	-	405	WP_012876936.1	type II toxin-antitoxin system VapC family toxin	Toxin
XCEL_RS00770	182857..183087	-	231	WP_012876937.1	antitoxin	Antitoxin
XCEL_RS00775	183215..183751	-	537	WP_012876938.1	PH domain-containing protein	-
XCEL_RS00780	183882..184592	-	711	WP_148220632.1	histidine phosphatase family protein	-
XCEL_RS17480	184884..185249	-	366	WP_012876941.1	DUF1049 domain-containing protein	-
XCEL_RS00790	185362..186369	-	1008	WP_148220817.1	acyl-CoA desaturase	-
XCEL_RS00795	186555..187457	-	903	WP_012876943.1	DNA-3-methyladenine glycosylase	-
XCEL_RS00800	187468..188043	-	576	WP_012876944.1	ribonuclease HI	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-125)

Antitoxin

• SpoVT-AbrB domain (7-50)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 14459.44 Da
• Isoelectric Point: 5.1579

>T24445 WP_012876936.1 NC_013530:c182860-182456 [Xylanimonas cellulosilytica DSM 15894]
VTTLYLLDTNVLIELLRGRGAVARKQLEAAEGRIGVSTISTMELDYGVERSSDPARSRQALDGLLSLMDEIPFDAHAAMH
SGRIRAHLAAAGTPIGPYDVLIAGHARSLGTVLVTHNTDEFSRVPGLEIEDWLV

Nucleotide

• Length: 405 bp

>T24445 NC_013530:c182860-182456 [Xylanimonas cellulosilytica DSM 15894]
GTGACGACGCTCTATCTCCTGGACACGAACGTCCTCATCGAGCTGCTGCGCGGACGCGGCGCCGTCGCACGCAAGCAGCT
CGAAGCCGCCGAGGGCCGCATCGGGGTGTCGACCATCAGCACGATGGAGCTGGACTACGGGGTCGAGCGGTCGTCAGACC
CGGCCCGGAGTCGCCAGGCGCTCGACGGGCTCCTGTCTCTCATGGACGAGATCCCCTTCGACGCCCACGCCGCCATGCAC
AGCGGCCGGATCCGCGCGCACCTCGCCGCCGCCGGCACGCCCATCGGACCGTACGACGTCCTGATCGCCGGGCACGCCCG
GTCGCTCGGGACGGTGCTCGTCACCCACAACACCGACGAGTTCTCTCGTGTCCCCGGGCTGGAGATCGAGGACTGGCTCG
TGTAG

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8548.69 Da
• Isoelectric Point: 9.1348

>AT24445 WP_012876937.1 NC_013530:c183087-182857 [Xylanimonas cellulosilytica DSM 15894]
MTTTRLFRSNTTQAVRLPKPVAFPETVRDVEIRVVGRSRVITPVGSAWAEWFDHGLVVPDFPGGRDQGVAQEREAW

Nucleotide

• Length: 231 bp

>AT24445 NC_013530:c183087-182857 [Xylanimonas cellulosilytica DSM 15894]
ATGACCACGACGCGGTTGTTCCGCAGCAACACCACCCAGGCGGTCCGCTTGCCCAAGCCCGTCGCGTTCCCTGAGACCGT
GCGCGACGTCGAGATCCGCGTCGTCGGGCGGTCGCGGGTGATCACTCCAGTTGGATCGGCGTGGGCCGAGTGGTTCGATC
ACGGGCTTGTGGTCCCCGACTTCCCCGGCGGCCGGGACCAGGGCGTCGCCCAGGAGCGCGAGGCCTGGTGA

Structures

Antitoxin

• AlphaFold DB: D1BU28