Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 181215..181744 Replicon chromosome
Accession NZ_CP097022
Organism Enterococcus faecium strain AT45b

Toxin (Protein)


Gene name relE Uniprot ID C9B8W9
Locus tag M2917_RS00910 Protein ID WP_002294198.1
Coordinates 181478..181744 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C9B8W8
Locus tag M2917_RS00905 Protein ID WP_002294199.1
Coordinates 181215..181478 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2917_RS00895 (M2917_00895) 178590..180413 + 1824 WP_002294202.1 APC family permease -
M2917_RS00900 (M2917_00900) 180555..180740 - 186 WP_002294201.1 hypothetical protein -
M2917_RS14405 180747..180875 + 129 WP_002294200.1 hypothetical protein -
M2917_RS00905 (M2917_00905) 181215..181478 + 264 WP_002294199.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
M2917_RS00910 (M2917_00910) 181478..181744 + 267 WP_002294198.1 Txe/YoeB family addiction module toxin Toxin
M2917_RS00915 (M2917_00915) 181945..182433 + 489 WP_002294196.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
M2917_RS00920 (M2917_00920) 182975..183646 - 672 WP_002319469.1 ABC transporter permease -
M2917_RS00925 (M2917_00925) 183643..184560 - 918 WP_086286322.1 osmoprotectant ABC transporter substrate-binding protein -
M2917_RS00930 (M2917_00930) 184557..185198 - 642 WP_214359207.1 ABC transporter permease -
M2917_RS00935 (M2917_00935) 185202..186377 - 1176 WP_002294192.1 betaine/proline/choline family ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(22-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10646.11 Da        Isoelectric Point: 9.9931

>T244449 WP_002294198.1 NZ_CP097022:181478-181744 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQSNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10016.03 Da        Isoelectric Point: 4.1207

>AT244449 WP_002294199.1 NZ_CP097022:181215-181478 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
DIDWEAL

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FMA0

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZU84

References