Detailed information of TA system TA024444

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1983058..1983710
• Replicon: chromosome
• Accession: NC_013520
• Organism: Veillonella parvula DSM 2008

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: VPAR_RS08835
• Protein ID: WP_012864932.1
• Coordinates: 1983525..1983710 (-)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: D1BPU6
• Locus tag: VPAR_RS08830
• Protein ID: WP_012864931.1
• Coordinates: 1983058..1983456 (-)
• Length: 133 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
VPAR_RS08805	1979957..1980586	-	630	WP_012864926.1	superoxide dismutase	-
VPAR_RS08810	1980947..1981486	-	540	WP_012864927.1	cysteine hydrolase	-
VPAR_RS08815	1981550..1982062	-	513	WP_012864928.1	phosphatidylglycerophosphatase A	-
VPAR_RS08820	1982076..1982468	-	393	WP_012864929.1	hypothetical protein	-
VPAR_RS08825	1982570..1982914	-	345	WP_012864930.1	alkylphosphonate utilization protein	-
VPAR_RS08830	1983058..1983456	-	399	WP_012864931.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
VPAR_RS08835	1983525..1983710	-	186	WP_012864932.1	type II toxin-antitoxin system HicA family toxin	Toxin
VPAR_RS08840	1983800..1984159	-	360	WP_012864933.1	MerR family transcriptional regulator	-
VPAR_RS08845	1984226..1984603	+	378	WP_012864934.1	carboxymuconolactone decarboxylase family protein	-
VPAR_RS08850	1985103..1985600	-	498	WP_012864936.1	ECF transporter S component	-
VPAR_RS08855	1985833..1986399	+	567	WP_012864937.1	NAD(P)H-dependent oxidoreductase	-
VPAR_RS08860	1986537..1986824	-	288	WP_012864938.1	DUF2695 domain-containing protein	-
VPAR_RS08865	1986838..1987344	-	507	WP_012864939.1	YfbM family protein	-
VPAR_RS08870	1987448..1988041	-	594	WP_012864940.1	hypothetical protein	-
VPAR_RS08875	1988071..1988442	-	372	Protein_1723	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (6-111)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 7038.46 Da
• Isoelectric Point: 10.8174

>T24444 WP_012864932.1 NC_013520:c1983710-1983525 [Veillonella parvula DSM 2008]
MTTPKELMKDLKKDGWYIDRIKGSHHILKHPIKAGRVTIPLHKEDLKPKTLQTILKQAGLK

Nucleotide

• Length: 186 bp

>T24444 NC_013520:c1983710-1983525 [Veillonella parvula DSM 2008]
TTGACTACACCTAAAGAATTGATGAAGGATTTAAAAAAAGATGGTTGGTATATTGATAGAATTAAAGGCTCGCATCATAT
ACTAAAGCATCCAATAAAAGCTGGTCGTGTAACGATTCCGCTACATAAGGAAGATTTAAAGCCTAAAACATTACAAACAA
TCTTGAAACAAGCGGGGCTTAAATAG

Antitoxin

Protein

• Length: 133 a.a.
• Molecular weight: 15072.06 Da
• Isoelectric Point: 4.2501

>AT24444 WP_012864931.1 NC_013520:c1983456-1983058 [Veillonella parvula DSM 2008]
MRKEMYPAIFSTDGKNGYTVSFPDLLGCVTEGDTLCEAVEMAEDALGIYLYSLSEDGEEFPEASNPIDIKCNKGEFIDLV
KWDEEEYLKRTDNKAVKKTLTIPSWLNHKAEEKQLNFSQILQRALKQELELV

Nucleotide

• Length: 399 bp

>AT24444 NC_013520:c1983456-1983058 [Veillonella parvula DSM 2008]
ATGAGAAAGGAAATGTACCCAGCTATCTTTAGTACAGATGGTAAAAATGGATATACGGTAAGTTTTCCAGATTTATTAGG
CTGTGTAACTGAAGGCGATACTTTATGTGAAGCCGTAGAGATGGCTGAAGATGCACTAGGTATTTACTTGTATTCATTGA
GTGAAGATGGCGAGGAATTTCCAGAAGCAAGTAATCCAATCGATATTAAATGTAATAAAGGTGAATTCATAGATTTAGTA
AAATGGGATGAAGAGGAATATTTAAAAAGAACCGATAATAAAGCTGTAAAAAAGACCCTTACAATACCAAGCTGGTTAAA
TCATAAAGCTGAAGAGAAGCAACTTAATTTTTCACAAATTTTACAGAGAGCATTAAAGCAAGAGTTAGAATTAGTATAA

Structures

Antitoxin

• AlphaFold DB: D1BPU6