244437

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2656564..2657135 Replicon chromosome
Accession NZ_CP097020
Organism Enterococcus faecalis strain AT46a

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag M2918_RS12615 Protein ID WP_174114068.1
Coordinates 2656564..2656905 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID R3JGB1
Locus tag M2918_RS12620 Protein ID WP_002354773.1
Coordinates 2656905..2657135 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2918_RS12610 (2652579) 2652579..2656193 - 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -
M2918_RS12615 (2656564) 2656564..2656905 - 342 WP_174114068.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
M2918_RS12620 (2656905) 2656905..2657135 - 231 WP_002354773.1 hypothetical protein Antitoxin
M2918_RS12625 (2657550) 2657550..2657765 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
M2918_RS12630 (2657904) 2657904..2658896 + 993 WP_002378862.1 biotin--[acetyl-CoA-carboxylase] ligase -
M2918_RS12635 (2659063) 2659063..2659701 - 639 WP_002378863.1 lytic polysaccharide monooxygenase -
M2918_RS12640 (2660387) 2660387..2662003 + 1617 WP_174114069.1 phosphatase PAP2/LCP family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13177.42 Da        Isoelectric Point: 8.8678

>T244437 WP_174114068.1 NZ_CP097020:c2656905-2656564 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPIISTIKNIPTRYTLPDDIETHGQVVISQ
LQSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.67 Da        Isoelectric Point: 4.3313

>AT244437 WP_002354773.1 NZ_CP097020:c2657135-2656905 [Enterococcus faecalis]
MLTTKSRRQGSSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2A812

References