Detailed information of TA system TA024443

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-relB/YoeB-DinJ
• Location: 1544277..1544806
• Replicon: chromosome
• Accession: NC_013512
• Organism: Sulfurospirillum deleyianum DSM 6946

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: D1B369
• Locus tag: SDEL_RS07685
• Protein ID: WP_012857289.1
• Coordinates: 1544277..1544546 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D1B370
• Locus tag: SDEL_RS07690
• Protein ID: WP_012857290.1
• Coordinates: 1544543..1544806 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SDEL_RS07660	1540029..1540517	-	489	WP_012857284.1	3-isopropylmalate dehydratase small subunit	-
SDEL_RS07665	1540727..1541041	+	315	WP_012857285.1	nucleotidyltransferase domain-containing protein	-
SDEL_RS07670	1541034..1541399	+	366	WP_012857286.1	DUF86 domain-containing protein	-
SDEL_RS11855	1541446..1541856	+	411	WP_012857287.1	hypothetical protein	-
SDEL_RS07675	1541809..1543176	-	1368	WP_012856485.1	transposase	-
SDEL_RS07680	1543321..1544229	+	909	WP_012857288.1	potassium channel family protein	-
SDEL_RS07685	1544277..1544546	-	270	WP_012857289.1	Txe/YoeB family addiction module toxin	Toxin
SDEL_RS07690	1544543..1544806	-	264	WP_012857290.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
SDEL_RS07695	1544897..1545460	-	564	WP_148209284.1	rRNA pseudouridine synthase	-
SDEL_RS07700	1545469..1546269	-	801	WP_012857292.1	ATP-binding cassette domain-containing protein	-
SDEL_RS07705	1546382..1546696	+	315	WP_012857293.1	metalloregulator ArsR/SmtB family transcription factor	-
SDEL_RS07710	1546693..1547952	+	1260	WP_012857294.1	arsenic transporter	-
SDEL_RS07715	1548029..1548946	+	918	WP_012857295.1	protein-methionine-sulfoxide reductase catalytic subunit MsrP	-
SDEL_RS07720	1548943..1549485	+	543	WP_012857296.1	ferric reductase-like transmembrane domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (7-86)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (6-50)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10707.26 Da
• Isoelectric Point: 8.8910

>T24443 WP_012857289.1 NC_013512:c1544546-1544277 [Sulfurospirillum deleyianum DSM 6946]
MSQKIVFTQIAWDEYLSWQSEDKKTLKRINQLLSDIMRNGNMGIGKPERLRGDLSEYWSRRIDEKNRIVYRILEETIEVV
QCKTHYADK

Nucleotide

• Length: 270 bp

>T24443 NC_013512:c1544546-1544277 [Sulfurospirillum deleyianum DSM 6946]
ATGAGTCAAAAAATCGTTTTTACGCAAATAGCATGGGACGAATATCTTTCATGGCAGAGTGAAGATAAAAAGACGCTAAA
ACGCATCAATCAACTCTTGTCAGACATCATGCGAAATGGCAACATGGGCATCGGCAAACCTGAGCGGCTAAGAGGCGATT
TGTCAGAGTATTGGAGTCGTAGGATTGATGAAAAAAATCGCATTGTTTACCGCATTTTAGAAGAGACCATCGAGGTCGTA
CAATGTAAAACGCATTATGCGGATAAGTAG

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9859.35 Da
• Isoelectric Point: 8.5179

>AT24443 WP_012857290.1 NC_013512:c1544806-1544543 [Sulfurospirillum deleyianum DSM 6946]
MAQVNINIRMDETVKKQAEELFGELGLNMTTAFNMFVRQALNRGGIPFEVVRKDAFYSPYNQAKLRESIASTDKTVKSLD
ALEKMAQ

Nucleotide

• Length: 264 bp

>AT24443 NC_013512:c1544806-1544543 [Sulfurospirillum deleyianum DSM 6946]
ATGGCACAAGTAAACATCAATATTCGCATGGATGAAACGGTGAAAAAACAAGCTGAAGAGCTTTTTGGTGAGTTAGGGCT
TAACATGACCACAGCGTTTAATATGTTTGTACGTCAAGCACTCAACCGTGGTGGCATTCCTTTTGAAGTGGTGCGTAAAG
ATGCGTTTTATAGCCCATACAATCAAGCAAAACTACGAGAGTCCATTGCCAGTACCGACAAAACGGTAAAAAGCCTTGAT
GCGTTAGAAAAGATGGCTCAATGA

Structures

Toxin

• AlphaFold DB: D1B369

Antitoxin

• AlphaFold DB: D1B370