Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 184602..185131 Replicon chromosome
Accession NZ_CP097014
Organism Enterococcus faecium strain AT47b

Toxin (Protein)


Gene name relE Uniprot ID C9B8W9
Locus tag M2920_RS00915 Protein ID WP_002294198.1
Coordinates 184865..185131 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C9B8W8
Locus tag M2920_RS00910 Protein ID WP_002294199.1
Coordinates 184602..184865 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2920_RS00900 (M2920_00900) 181977..183800 + 1824 WP_002294202.1 APC family permease -
M2920_RS00905 (M2920_00905) 183942..184127 - 186 WP_002294201.1 hypothetical protein -
M2920_RS14140 184134..184262 + 129 WP_002294200.1 hypothetical protein -
M2920_RS00910 (M2920_00910) 184602..184865 + 264 WP_002294199.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
M2920_RS00915 (M2920_00915) 184865..185131 + 267 WP_002294198.1 Txe/YoeB family addiction module toxin Toxin
M2920_RS00920 (M2920_00920) 185332..185820 + 489 WP_002294196.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
M2920_RS00925 (M2920_00925) 185883..186050 + 168 WP_002294195.1 hypothetical protein -
M2920_RS00930 (M2920_00930) 186362..187033 - 672 WP_002319469.1 ABC transporter permease -
M2920_RS00935 (M2920_00935) 187030..187947 - 918 WP_002294193.1 osmoprotectant ABC transporter substrate-binding protein -
M2920_RS00940 (M2920_00940) 187944..188585 - 642 WP_002293405.1 ABC transporter permease -
M2920_RS00945 (M2920_00945) 188589..189764 - 1176 WP_002294192.1 betaine/proline/choline family ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(22-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10646.11 Da        Isoelectric Point: 9.9931

>T244417 WP_002294198.1 NZ_CP097014:184865-185131 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQSNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10016.03 Da        Isoelectric Point: 4.1207

>AT244417 WP_002294199.1 NZ_CP097014:184602-184865 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
DIDWEAL

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FMA0

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZU84

References