Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 901853..902424 Replicon chromosome
Accession NZ_CP097010
Organism Enterococcus faecalis strain AT48

Toxin (Protein)


Gene name mazF Uniprot ID R3GRA7
Locus tag M2921_RS04195 Protein ID WP_002360937.1
Coordinates 901853..902194 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID S4CGQ1
Locus tag M2921_RS04200 Protein ID WP_002367500.1
Coordinates 902194..902424 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2921_RS04190 (897868) 897868..901482 - 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -
M2921_RS04195 (901853) 901853..902194 - 342 WP_002360937.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
M2921_RS04200 (902194) 902194..902424 - 231 WP_002367500.1 hypothetical protein Antitoxin
M2921_RS04205 (902830) 902830..903045 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
M2921_RS04210 (903184) 903184..904176 + 993 WP_002398510.1 biotin--[acetyl-CoA-carboxylase] ligase -
M2921_RS04215 (904343) 904343..904981 - 639 WP_002378863.1 lytic polysaccharide monooxygenase -
M2921_RS04220 (905665) 905665..907281 + 1617 WP_002372620.1 phosphatase PAP2/LCP family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13165.41 Da        Isoelectric Point: 9.3988

>T244402 WP_002360937.1 NZ_CP097010:c902194-901853 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETHGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8704.69 Da        Isoelectric Point: 4.3313

>AT244402 WP_002367500.1 NZ_CP097010:c902424-902194 [Enterococcus faecalis]
MLTTKSRRQGNSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2A7G9

Antitoxin

Source ID Structure
AlphaFold DB S4CGQ1

References