244389

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2615439..2616010 Replicon chromosome
Accession NZ_CP097008
Organism Enterococcus faecalis strain AT50

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag M2923_RS12300 Protein ID WP_002354774.1
Coordinates 2615439..2615780 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID S4CGQ1
Locus tag M2923_RS12305 Protein ID WP_002367500.1
Coordinates 2615780..2616010 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2923_RS12295 (2611454) 2611454..2615068 - 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -
M2923_RS12300 (2615439) 2615439..2615780 - 342 WP_002354774.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
M2923_RS12305 (2615780) 2615780..2616010 - 231 WP_002367500.1 hypothetical protein Antitoxin
M2923_RS12310 (2616333) 2616333..2616548 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
M2923_RS12315 (2616687) 2616687..2617679 + 993 WP_002358973.1 biotin--[acetyl-CoA-carboxylase] ligase -
M2923_RS12320 (2617746) 2617746..2618378 - 633 WP_002358972.1 RloB family protein -
M2923_RS12325 (2618387) 2618387..2619682 - 1296 WP_002410675.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13156.40 Da        Isoelectric Point: 9.3984

>T244389 WP_002354774.1 NZ_CP097008:c2615780-2615439 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETQGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8704.69 Da        Isoelectric Point: 4.3313

>AT244389 WP_002367500.1 NZ_CP097008:c2616010-2615780 [Enterococcus faecalis]
MLTTKSRRQGNSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S4CGQ1

References