Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3091850..3092513 Replicon chromosome
Accession NC_013508
Organism Edwardsiella tarda EIB202

Toxin (Protein)


Gene name cptA Uniprot ID A0A411H3S7
Locus tag ETAE_RS13695 Protein ID WP_034167931.1
Coordinates 3091850..3092266 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID D0ZDY6
Locus tag ETAE_RS13700 Protein ID WP_012849755.1
Coordinates 3092247..3092513 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ETAE_RS13675 (ETAE_2927) 3087781..3089514 - 1734 WP_012849750.1 single-stranded-DNA-specific exonuclease RecJ -
ETAE_RS13680 (ETAE_2928) 3089519..3090235 - 717 WP_012849751.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ETAE_RS13685 (ETAE_2929) 3090263..3091162 - 900 WP_012849752.1 site-specific tyrosine recombinase XerD -
ETAE_RS13690 (ETAE_2930) 3091313..3091825 + 513 WP_012849753.1 flavodoxin FldB -
ETAE_RS13695 (ETAE_2931) 3091850..3092266 - 417 WP_034167931.1 protein YgfX Toxin
ETAE_RS13700 (ETAE_2932) 3092247..3092513 - 267 WP_012849755.1 FAD assembly factor SdhE Antitoxin
ETAE_RS13705 (ETAE_2933) 3092867..3093865 + 999 WP_012849756.1 tRNA-modifying protein YgfZ -
ETAE_RS13710 (ETAE_2934) 3093908..3094732 - 825 WP_012849757.1 shikimate 5-dehydrogenase -
ETAE_RS13715 (ETAE_2935) 3094891..3095763 - 873 WP_012849758.1 nucleoside-specific channel-forming protein Tsx -
ETAE_RS13720 (ETAE_2937) 3096372..3097022 + 651 WP_015462279.1 hemolysin III family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 16213.03 Da        Isoelectric Point: 11.6049

>T24438 WP_034167931.1 NC_013508:c3092266-3091850 [Edwardsiella tarda EIB202]
VVLWRCNVHVSWRTQVMFLLGHGALVLAILLAPWPENYSVFWLILLVAVIFECIRSQRRIARNRGELQLLAPQVWHWQLR
EWRLARRPWVSDLGALLILQSTHGAPCRRRLWLAADSMSREEWGQLRRTLLDAGDDRA

Download         Length: 417 bp

>T24438 NC_013508:c3092266-3091850 [Edwardsiella tarda EIB202]
GTGGTCCTTTGGCGCTGTAATGTTCACGTCTCCTGGCGTACCCAGGTGATGTTTCTGCTGGGGCACGGCGCGCTGGTACT
GGCGATCCTGCTGGCGCCCTGGCCGGAAAACTACAGCGTATTCTGGCTGATTCTGCTGGTGGCGGTGATCTTTGAGTGTA
TCCGCAGCCAGCGCCGGATTGCGCGTAACCGCGGTGAGCTGCAGCTGCTGGCGCCGCAGGTGTGGCACTGGCAGCTGCGC
GAGTGGCGCCTGGCCCGACGCCCTTGGGTTAGCGATCTGGGGGCGCTGCTGATCCTGCAGAGTACCCATGGTGCGCCGTG
CCGCCGCCGTCTGTGGCTGGCGGCCGACAGCATGAGCCGCGAAGAGTGGGGGCAGCTGCGCCGCACGCTGCTCGATGCGG
GCGACGATCGCGCATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10318.90 Da        Isoelectric Point: 5.6951

>AT24438 WP_012849755.1 NC_013508:c3092513-3092247 [Edwardsiella tarda EIB202]
MDINNKARVHWACRRGMRELDIAIMPFFEHEYDALNDADKQTFVRLLACDDPELFKWLMNQGKPDDADLARMITLIQTRN
KERGPLAL

Download         Length: 267 bp

>AT24438 NC_013508:c3092513-3092247 [Edwardsiella tarda EIB202]
ATGGATATCAATAATAAAGCGCGGGTTCACTGGGCGTGCCGCCGCGGAATGCGCGAGCTGGATATCGCCATCATGCCTTT
CTTTGAACATGAGTATGATGCGCTTAACGATGCCGATAAACAGACCTTTGTCCGCCTGCTGGCCTGTGACGATCCTGAGC
TATTTAAATGGCTGATGAACCAGGGTAAGCCGGATGACGCCGATCTGGCCCGCATGATTACGCTGATTCAGACGCGAAAT
AAAGAACGTGGTCCTTTGGCGCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A411H3S7

Antitoxin

Source ID Structure
AlphaFold DB A0A034T2Q8

References