244357

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_19(antitoxin)
Location 2320232..2321265 Replicon chromosome
Accession NZ_CP097004
Organism Enterococcus faecalis strain LS05-2

Toxin (Protein)


Gene name IrrE Uniprot ID -
Locus tag M2925_RS11030 Protein ID WP_142429825.1
Coordinates 2320612..2321265 (+) Length 218 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag M2925_RS11025 Protein ID WP_010824178.1
Coordinates 2320232..2320615 (+) Length 128 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2925_RS10990 (2316581) 2316581..2316961 - 381 WP_002402315.1 DUF86 domain-containing protein -
M2925_RS10995 (2316951) 2316951..2317277 - 327 WP_002394268.1 nucleotidyltransferase domain-containing protein -
M2925_RS11000 (2317337) 2317337..2317630 - 294 WP_002394269.1 hypothetical protein -
M2925_RS11005 (2317672) 2317672..2317824 - 153 WP_002371433.1 hypothetical protein -
M2925_RS11010 (2318409) 2318409..2318825 - 417 WP_219259950.1 DUF961 family protein -
M2925_RS11015 (2318825) 2318825..2319151 - 327 WP_219259948.1 hypothetical protein -
M2925_RS11020 (2319237) 2319237..2319488 - 252 WP_219259946.1 hypothetical protein -
M2925_RS11025 (2320232) 2320232..2320615 + 384 WP_010824178.1 helix-turn-helix transcriptional regulator Antitoxin
M2925_RS11030 (2320612) 2320612..2321265 + 654 WP_142429825.1 ImmA/IrrE family metallo-endopeptidase Toxin
M2925_RS11035 (2321304) 2321304..2321639 + 336 WP_002402309.1 helix-turn-helix domain-containing protein -
M2925_RS11040 (2321677) 2321677..2323008 - 1332 WP_219259944.1 FAD-dependent oxidoreductase -
M2925_RS11045 (2323112) 2323112..2323348 - 237 Protein_2149 aldo/keto reductase -
M2925_RS11050 (2323420) 2323420..2324469 - 1050 WP_219259942.1 hypothetical protein -
M2925_RS11055 (2324711) 2324711..2324938 - 228 WP_219259940.1 hypothetical protein -
M2925_RS11060 (2325030) 2325030..2325224 - 195 Protein_2152 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2256509..2321522 65013


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(80-181)

Antitoxin

Cro/C1-type helix-turn-helix domain

(5-63)


Sequences

Toxin        


Download         Length: 218 a.a.        Molecular weight: 26078.05 Da        Isoelectric Point: 6.4968

>T244357 WP_142429825.1 NZ_CP097004:2320612-2321265 [Enterococcus faecalis]
MIGLLLVNFISKELYFEAFNFSNELIKEVSYYSSKNIEQVKCFDIEKYVKEVEDVEFVEYTFQKQLKRRMLGSISKVDDE
VIITTNKELMLERKNFTKMHEIMHYYIDIPKINNATHTFSDILLKNGYLMEDFPKEYRANVGASMLMANDQALFYALKKF
YSFEEIAQYFFMSKSALRNRLIEHLMYVNNCTFAHANTLFNNYYFHKETDIYRFIFN

Download         Length: 654 bp

Antitoxin


Download         Length: 128 a.a.        Molecular weight: 15032.08 Da        Isoelectric Point: 5.3750

>AT244357 WP_010824178.1 NZ_CP097004:2320232-2320615 [Enterococcus faecalis]
VQPLAKRLQLLREEKEWTKTYVAKQLGLNNLGTYANWEYGTREPDSEMLSKIASLYDVSTDFLLGRTEERIHLNDKEKIG
KNIISHFRLNTSDMDIEDIEELEEELIDFQDFLIKKAKEKKKRNKKD

Download         Length: 384 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References