Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2564676..2565247 Replicon chromosome
Accession NZ_CP097002
Organism Enterococcus faecalis strain LS06-1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag M2926_RS12045 Protein ID WP_002354774.1
Coordinates 2564676..2565017 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID S4CGQ1
Locus tag M2926_RS12050 Protein ID WP_002367500.1
Coordinates 2565017..2565247 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2926_RS12040 (2560691) 2560691..2564305 - 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -
M2926_RS12045 (2564676) 2564676..2565017 - 342 WP_002354774.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
M2926_RS12050 (2565017) 2565017..2565247 - 231 WP_002367500.1 hypothetical protein Antitoxin
M2926_RS12055 (2565577) 2565577..2565792 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
M2926_RS12060 (2565931) 2565931..2566923 + 993 WP_002358973.1 biotin--[acetyl-CoA-carboxylase] ligase -
M2926_RS12065 (2567187) 2567187..2567825 - 639 WP_002378863.1 lytic polysaccharide monooxygenase -
M2926_RS12070 (2568512) 2568512..2570128 + 1617 WP_010715485.1 phosphatase PAP2/LCP family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13156.40 Da        Isoelectric Point: 9.3984

>T244349 WP_002354774.1 NZ_CP097002:c2565017-2564676 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETQGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8704.69 Da        Isoelectric Point: 4.3313

>AT244349 WP_002367500.1 NZ_CP097002:c2565247-2565017 [Enterococcus faecalis]
MLTTKSRRQGNSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S4CGQ1

References