Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4617299..4617894 Replicon chromosome
Accession NZ_CP096976
Organism Escherichia coli strain 17-07187

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag M2894_RS22570 Protein ID WP_000239579.1
Coordinates 4617299..4617649 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag M2894_RS22575 Protein ID WP_001223208.1
Coordinates 4617643..4617894 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2894_RS22550 (4612575) 4612575..4613597 - 1023 WP_001387274.1 ABC transporter permease -
M2894_RS22555 (4613611) 4613611..4615113 - 1503 WP_000205794.1 sugar ABC transporter ATP-binding protein -
M2894_RS22560 (4615423) 4615423..4616379 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
M2894_RS22565 (4616689) 4616689..4617219 + 531 WP_000055072.1 inorganic diphosphatase -
M2894_RS22570 (4617299) 4617299..4617649 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
M2894_RS22575 (4617643) 4617643..4617894 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
M2894_RS22580 (4618106) 4618106..4618447 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
M2894_RS22585 (4618450) 4618450..4622229 - 3780 WP_248910678.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T244331 WP_000239579.1 NZ_CP096976:c4617649-4617299 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT244331 WP_001223208.1 NZ_CP096976:c4617894-4617643 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References