Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3918145..3918763 Replicon chromosome
Accession NZ_CP096976
Organism Escherichia coli strain 17-07187

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag M2894_RS19260 Protein ID WP_001291435.1
Coordinates 3918545..3918763 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag M2894_RS19255 Protein ID WP_000344800.1
Coordinates 3918145..3918519 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2894_RS19245 (3913234) 3913234..3914427 + 1194 WP_001386618.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
M2894_RS19250 (3914450) 3914450..3917599 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
M2894_RS19255 (3918145) 3918145..3918519 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
M2894_RS19260 (3918545) 3918545..3918763 + 219 WP_001291435.1 HHA domain-containing protein Toxin
M2894_RS19265 (3918934) 3918934..3919485 + 552 WP_000102564.1 maltose O-acetyltransferase -
M2894_RS19270 (3919601) 3919601..3920071 + 471 WP_000136192.1 YlaC family protein -
M2894_RS19275 (3920235) 3920235..3921785 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
M2894_RS19280 (3921827) 3921827..3922180 - 354 WP_000878140.1 DUF1428 domain-containing protein -
M2894_RS19290 (3922559) 3922559..3922870 + 312 WP_000409911.1 MGMT family protein -
M2894_RS19295 (3922901) 3922901..3923473 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T244328 WP_001291435.1 NZ_CP096976:3918545-3918763 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT244328 WP_000344800.1 NZ_CP096976:3918145-3918519 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References