Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1066747..1067401 Replicon chromosome
Accession NZ_CP096976
Organism Escherichia coli strain 17-07187

Toxin (Protein)


Gene name cptA Uniprot ID F4NJ21
Locus tag M2894_RS05200 Protein ID WP_000244772.1
Coordinates 1066994..1067401 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag M2894_RS05195 Protein ID WP_000354046.1
Coordinates 1066747..1067013 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2894_RS05170 (1062034) 1062034..1062777 + 744 WP_000951964.1 SDR family oxidoreductase -
M2894_RS05175 (1062834) 1062834..1064267 - 1434 WP_001387034.1 6-phospho-beta-glucosidase BglA -
M2894_RS05180 (1064312) 1064312..1064623 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
M2894_RS05185 (1064787) 1064787..1065446 + 660 WP_000250274.1 hemolysin III family protein -
M2894_RS05190 (1065524) 1065524..1066504 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
M2894_RS05195 (1066747) 1066747..1067013 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
M2894_RS05200 (1066994) 1066994..1067401 + 408 WP_000244772.1 protein YgfX Toxin
M2894_RS05205 (1067441) 1067441..1067962 - 522 WP_001055874.1 flavodoxin FldB -
M2894_RS05210 (1068074) 1068074..1068970 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
M2894_RS05215 (1068995) 1068995..1069705 + 711 WP_000715208.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M2894_RS05220 (1069711) 1069711..1071444 + 1734 WP_000813220.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16048.02 Da        Isoelectric Point: 11.2511

>T244313 WP_000244772.1 NZ_CP096976:1066994-1067401 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT244313 WP_000354046.1 NZ_CP096976:1066747-1067013 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYB4

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References