Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 393774..394360 Replicon chromosome
Accession NZ_CP096976
Organism Escherichia coli strain 17-07187

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag M2894_RS01805 Protein ID WP_042014162.1
Coordinates 393774..394004 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag M2894_RS01810 Protein ID WP_000593555.1
Coordinates 394001..394360 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2894_RS01795 (389811) 389811..392546 + 2736 WP_000149085.1 ribosome-associated ATPase/putative transporter RbbA -
M2894_RS01800 (392546) 392546..393670 + 1125 WP_001216257.1 ABC transporter permease -
M2894_RS01805 (393774) 393774..394004 + 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
M2894_RS01810 (394001) 394001..394360 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
M2894_RS01815 (394480) 394480..394881 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
M2894_RS01820 (394887) 394887..395693 - 807 WP_000173630.1 nickel import ATP-binding protein NikE -
M2894_RS01825 (395690) 395690..396454 - 765 WP_001136229.1 nickel import ATP-binding protein NikD -
M2894_RS01830 (396454) 396454..397287 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
M2894_RS01835 (397284) 397284..398228 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T244310 WP_042014162.1 NZ_CP096976:393774-394004 [Escherichia coli]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT244310 WP_000593555.1 NZ_CP096976:394001-394360 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References