244301

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1769359..1769993 Replicon chromosome
Accession NZ_CP096972
Organism Sphingomonas sp. SUN039

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag M0209_RS08640 Protein ID WP_258887876.1
Coordinates 1769359..1769760 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag M0209_RS08645 Protein ID WP_258889603.1
Coordinates 1769772..1769993 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M0209_RS08610 (M0209_08600) 1765403..1766635 + 1233 WP_258887871.1 DNA sulfur modification protein DndB -
M0209_RS08615 (M0209_08605) 1766839..1767171 - 333 WP_258887872.1 Grx4 family monothiol glutaredoxin -
M0209_RS08620 (M0209_08610) 1767178..1767411 - 234 WP_258887873.1 BolA/IbaG family iron-sulfur metabolism protein -
M0209_RS08625 (M0209_08615) 1767411..1767734 - 324 WP_258887874.1 DUF1476 domain-containing protein -
M0209_RS08630 (M0209_08620) 1767768..1768766 - 999 WP_258889602.1 NADPH:quinone oxidoreductase family protein -
M0209_RS08635 (M0209_08625) 1768763..1769362 - 600 WP_258887875.1 3-isopropylmalate dehydratase small subunit -
M0209_RS08640 (M0209_08630) 1769359..1769760 - 402 WP_258887876.1 PIN domain-containing protein Toxin
M0209_RS08645 (M0209_08635) 1769772..1769993 - 222 WP_258889603.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
M0209_RS08650 (M0209_08640) 1770083..1770367 + 285 WP_258887877.1 helix-turn-helix transcriptional regulator -
M0209_RS08655 (M0209_08645) 1770423..1770830 + 408 WP_258887878.1 hypothetical protein -
M0209_RS08660 (M0209_08650) 1770835..1772268 - 1434 WP_258887879.1 3-isopropylmalate dehydratase large subunit -
M0209_RS08665 (M0209_08655) 1772277..1773176 - 900 WP_258887880.1 alpha/beta hydrolase -
M0209_RS08670 (M0209_08660) 1773220..1774506 - 1287 WP_258887881.1 serine hydrolase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-121)

Antitoxin

SpoVT-AbrB domain

(5-48)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14753.78 Da        Isoelectric Point: 5.6238

>T244301 WP_258887876.1 NZ_CP096972:c1769760-1769359 [Sphingomonas sp. SUN039]
MLDTNVCIRVIRNRPAAVAARFQSEVDDLAISTIVWHELLHGAEKSDRPAYHREKAEDFATRLTILNFDQAAAADAANIK
FVLGKKGQMIGPNDLLIAGHARSLGLQLITGNLGEFRRVDGLRCEDWLAEETE

Download         Length: 402 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8474.57 Da        Isoelectric Point: 4.7719

>AT244301 WP_258889603.1 NZ_CP096972:c1769993-1769772 [Sphingomonas sp. SUN039]
MASLFKSNRNQAVRIPKDMEFPADIKSVVIRKVGNSRILTPKDQIWLEYFAEPGVADFPDRDPQGEYEERESF

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References