Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4492741..4493999 Replicon chromosome
Accession NZ_CP096961
Organism Pseudomonas aeruginosa strain NY13932

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag M2J00_RS20695 Protein ID WP_003123189.1
Coordinates 4492741..4493496 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag M2J00_RS20700 Protein ID WP_003086329.1
Coordinates 4493631..4493999 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2J00_RS20685 (M2J00_20635) 4487914..4490457 + 2544 WP_003123188.1 acyl-homoserine-lactone acylase QuiP -
M2J00_RS20690 (M2J00_20640) 4490612..4491973 - 1362 WP_003081943.1 DNA recombination protein RmuC -
M2J00_RS20695 (M2J00_20645) 4492741..4493496 - 756 WP_003123189.1 RES family NAD+ phosphorylase Toxin
M2J00_RS20700 (M2J00_20650) 4493631..4493999 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
M2J00_RS20705 (M2J00_20655) 4494072..4495358 - 1287 WP_003123190.1 FAD-binding oxidoreductase -
M2J00_RS20710 (M2J00_20660) 4495414..4496907 - 1494 WP_003086325.1 aldehyde dehydrogenase family protein -
M2J00_RS20715 (M2J00_20665) 4497082..4497558 + 477 WP_003112531.1 hypothetical protein -
M2J00_RS20720 (M2J00_20670) 4497561..4497836 - 276 WP_010792073.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28267.46 Da        Isoelectric Point: 8.3428

>T244286 WP_003123189.1 NZ_CP096961:c4493496-4492741 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGMRLQAPPFSDHEAALTDIA
DYRAPQKLGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT244286 WP_003086329.1 NZ_CP096961:c4493999-4493631 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References