Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3485316..3486537 Replicon chromosome
Accession NZ_CP096961
Organism Pseudomonas aeruginosa strain NY13932

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag M2J00_RS15960 Protein ID WP_003102740.1
Coordinates 3485959..3486537 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag M2J00_RS15955 Protein ID WP_049304404.1
Coordinates 3485316..3485870 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2J00_RS15930 (M2J00_15895) 3480884..3481435 + 552 WP_003102727.1 XRE family transcriptional regulator -
M2J00_RS15935 (M2J00_15900) 3481432..3481830 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
M2J00_RS15940 (M2J00_15905) 3481843..3482166 - 324 WP_003102734.1 multidrug efflux SMR transporter -
M2J00_RS15945 (M2J00_15910) 3482497..3482958 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
M2J00_RS15950 (M2J00_15915) 3482963..3485158 + 2196 WP_004349295.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
M2J00_RS15955 (M2J00_15920) 3485316..3485870 + 555 WP_049304404.1 helix-turn-helix transcriptional regulator Antitoxin
M2J00_RS15960 (M2J00_15925) 3485959..3486537 + 579 WP_003102740.1 HD domain-containing protein Toxin
M2J00_RS15965 (M2J00_15930) 3486646..3487833 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
M2J00_RS15970 (M2J00_15935) 3487823..3489994 - 2172 WP_003114950.1 type I secretion system permease/ATPase -
M2J00_RS15975 (M2J00_15940) 3489984..3491261 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T244285 WP_003102740.1 NZ_CP096961:3485959-3486537 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20484.66 Da        Isoelectric Point: 8.1590

>AT244285 WP_049304404.1 NZ_CP096961:3485316-3485870 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLTPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07

Antitoxin

Source ID Structure

References