Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1859695..1861203 Replicon chromosome
Accession NZ_CP096961
Organism Pseudomonas aeruginosa strain NY13932

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag M2J00_RS08640 Protein ID WP_012613851.1
Coordinates 1859695..1860282 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag M2J00_RS08645 Protein ID WP_012613852.1
Coordinates 1860349..1861203 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2J00_RS08635 (M2J00_08625) 1855950..1859429 - 3480 WP_023115144.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
M2J00_RS08640 (M2J00_08630) 1859695..1860282 + 588 WP_012613851.1 GNAT family protein Toxin
M2J00_RS08645 (M2J00_08635) 1860349..1861203 + 855 WP_012613852.1 AraC family transcriptional regulator Antitoxin
M2J00_RS08650 (M2J00_08640) 1861300..1863465 + 2166 WP_003091606.1 TonB-dependent receptor family protein -
M2J00_RS08655 (M2J00_08645) 1863640..1865514 + 1875 WP_023128709.1 MFS transporter -
M2J00_RS08660 (M2J00_08650) 1865575..1865784 - 210 WP_003091604.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21929.29 Da        Isoelectric Point: 9.8676

>T244284 WP_012613851.1 NZ_CP096961:1859695-1860282 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAVLEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31959.27 Da        Isoelectric Point: 7.3276

>AT244284 WP_012613852.1 NZ_CP096961:1860349-1861203 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHADSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLPVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References