Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 142227..142732 Replicon chromosome
Accession NZ_CP096961
Organism Pseudomonas aeruginosa strain NY13932

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag M2J00_RS00650 Protein ID WP_003083773.1
Coordinates 142227..142508 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag M2J00_RS00655 Protein ID WP_003083775.1
Coordinates 142505..142732 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2J00_RS00625 (M2J00_00625) 137478..138827 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
M2J00_RS00630 (M2J00_00630) 138876..139562 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
M2J00_RS00635 (M2J00_00635) 139663..140397 + 735 WP_003117208.1 GntR family transcriptional regulator -
M2J00_RS00640 (M2J00_00640) 140577..140987 + 411 WP_003101225.1 aegerolysin family protein -
M2J00_RS00645 (M2J00_00645) 141019..141927 - 909 WP_003083769.1 LysR family transcriptional regulator -
M2J00_RS00650 (M2J00_00650) 142227..142508 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
M2J00_RS00655 (M2J00_00655) 142505..142732 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
M2J00_RS00660 (M2J00_00660) 142908..143528 - 621 WP_003101226.1 hypothetical protein -
M2J00_RS00665 (M2J00_00665) 143629..144129 + 501 WP_003112629.1 LEA type 2 family protein -
M2J00_RS00670 (M2J00_00670) 144202..144543 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
M2J00_RS00675 (M2J00_00675) 144625..146052 - 1428 WP_003083784.1 GABA permease -
M2J00_RS00680 (M2J00_00680) 146221..147714 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T244282 WP_003083773.1 NZ_CP096961:c142508-142227 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT244282 WP_003083775.1 NZ_CP096961:c142732-142505 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References