244279

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4784731..4785989 Replicon chromosome
Accession NZ_CP096960
Organism Pseudomonas aeruginosa strain NY11254

Toxin (Protein)


Gene name - Uniprot ID V6AJ34
Locus tag M2I99_RS22340 Protein ID WP_003086331.1
Coordinates 4784731..4785486 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag M2I99_RS22345 Protein ID WP_003086329.1
Coordinates 4785621..4785989 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2I99_RS22330 (M2I99_22275) 4779902..4782445 + 2544 WP_003086335.1 acyl-homoserine-lactone acylase QuiP -
M2I99_RS22335 (M2I99_22280) 4782600..4783961 - 1362 WP_003081943.1 DNA recombination protein RmuC -
M2I99_RS22340 (M2I99_22285) 4784731..4785486 - 756 WP_003086331.1 RES family NAD+ phosphorylase Toxin
M2I99_RS22345 (M2I99_22290) 4785621..4785989 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
M2I99_RS22350 (M2I99_22295) 4786062..4787348 - 1287 WP_003086327.1 FAD-binding oxidoreductase -
M2I99_RS22355 (M2I99_22300) 4787404..4788897 - 1494 WP_003086325.1 aldehyde dehydrogenase family protein -
M2I99_RS22360 (M2I99_22305) 4789072..4789548 + 477 WP_003086322.1 hypothetical protein -
M2I99_RS22365 (M2I99_22310) 4789551..4789826 - 276 WP_023098713.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28236.34 Da        Isoelectric Point: 7.7294

>T244279 WP_003086331.1 NZ_CP096960:c4785486-4784731 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT244279 WP_003086329.1 NZ_CP096960:c4785989-4785621 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AJ34

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References