Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3264501..3265722 Replicon chromosome
Accession NZ_CP096960
Organism Pseudomonas aeruginosa strain NY11254

Toxin (Protein)


Gene name vapC Uniprot ID V6AG16
Locus tag M2I99_RS15620 Protein ID WP_003088107.1
Coordinates 3264501..3265079 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag M2I99_RS15625 Protein ID WP_003088112.1
Coordinates 3265168..3265722 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2I99_RS15605 (M2I99_15570) 3259777..3261054 + 1278 WP_003088104.1 TolC family protein -
M2I99_RS15610 (M2I99_15575) 3261044..3263215 + 2172 WP_003088105.1 type I secretion system permease/ATPase -
M2I99_RS15615 (M2I99_15580) 3263205..3264392 + 1188 WP_003088106.1 HlyD family efflux transporter periplasmic adaptor subunit -
M2I99_RS15620 (M2I99_15585) 3264501..3265079 - 579 WP_003088107.1 HD domain-containing protein Toxin
M2I99_RS15625 (M2I99_15590) 3265168..3265722 - 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
M2I99_RS15630 (M2I99_15595) 3265880..3268075 - 2196 WP_003088114.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
M2I99_RS15635 (M2I99_15600) 3268080..3268541 - 462 WP_003088117.1 (2Fe-2S)-binding protein -
M2I99_RS15640 (M2I99_15605) 3268872..3269195 + 324 WP_003102734.1 multidrug efflux SMR transporter -
M2I99_RS15645 (M2I99_15610) 3269208..3269606 + 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
M2I99_RS15650 (M2I99_15615) 3269603..3270154 - 552 WP_023098678.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-187)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21885.74 Da        Isoelectric Point: 5.3655

>T244277 WP_003088107.1 NZ_CP096960:c3265079-3264501 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDAKTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT244277 WP_003088112.1 NZ_CP096960:c3265722-3265168 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AG16

Antitoxin

Source ID Structure

References