Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1915540..1917048 Replicon chromosome
Accession NZ_CP096960
Organism Pseudomonas aeruginosa strain NY11254

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag M2I99_RS08895 Protein ID WP_073660237.1
Coordinates 1915540..1916127 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1C7C4U7
Locus tag M2I99_RS08900 Protein ID WP_003091607.1
Coordinates 1916194..1917048 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2I99_RS08890 (M2I99_08880) 1911795..1915274 - 3480 WP_003091610.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
M2I99_RS08895 (M2I99_08885) 1915540..1916127 + 588 WP_073660237.1 GNAT family protein Toxin
M2I99_RS08900 (M2I99_08890) 1916194..1917048 + 855 WP_003091607.1 AraC family transcriptional regulator Antitoxin
M2I99_RS08905 (M2I99_08895) 1917145..1919310 + 2166 WP_003091606.1 TonB-dependent receptor family protein -
M2I99_RS08910 (M2I99_08900) 1919485..1921359 + 1875 WP_003091605.1 MFS transporter -
M2I99_RS08915 (M2I99_08905) 1921420..1921629 - 210 WP_003091604.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21929.29 Da        Isoelectric Point: 9.8676

>T244276 WP_073660237.1 NZ_CP096960:1915540-1916127 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLVEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31895.20 Da        Isoelectric Point: 7.5295

>AT244276 WP_003091607.1 NZ_CP096960:1916194-1917048 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7C4U7

References